Cellular therapies and stem cell applications in trauma

Yuxuan Wang, Shibani Pati, Martin Schreiber

    Research output: Contribution to journalReview article

    4 Citations (Scopus)

    Abstract

    Background: As the leading cause of mortality in the United States, trauma management have improved drastically over the past few decades with improved resuscitation and hemorrhage control. Stem cells are being used in an attempt to augment healing from trauma. Data sources: PubMed and ClinicalTrials.gov were searched for published and registered pre-clinical and clinical trials for the application of stem cells to AKI, ARDS, shock, infection, TBI, wound healing, and bone healing. Conclusions: Stem cell therapy for augmentation of healing traumatic injuries appears safe, as demonstrated by completed phase I/II trials. Further large scale studies are needed to assess the clinical efficacy.

    Original languageEnglish (US)
    Pages (from-to)963-972
    Number of pages10
    JournalAmerican Journal of Surgery
    Volume215
    Issue number5
    DOIs
    StatePublished - May 1 2018

    Fingerprint

    Stem Cells
    Wounds and Injuries
    Information Storage and Retrieval
    Cell- and Tissue-Based Therapy
    PubMed
    Resuscitation
    Wound Healing
    Shock
    Therapeutics
    Clinical Trials
    Hemorrhage
    Bone and Bones
    Mortality
    Infection

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Cellular therapies and stem cell applications in trauma. / Wang, Yuxuan; Pati, Shibani; Schreiber, Martin.

    In: American Journal of Surgery, Vol. 215, No. 5, 01.05.2018, p. 963-972.

    Research output: Contribution to journalReview article

    Wang, Yuxuan ; Pati, Shibani ; Schreiber, Martin. / Cellular therapies and stem cell applications in trauma. In: American Journal of Surgery. 2018 ; Vol. 215, No. 5. pp. 963-972.
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