Cellular reprogramming to model and study epigenetic alterations in cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Although genetic mutations are required for cancer development, reversible non-genetic alterations also play a pivotal role in cancer progression. Failure of well-orchestrated gene regulation by chromatin states and master transcription factors can be one such non-genetic etiology for cancer development. Master transcription factor-mediated cellular reprogramming of human cancer cells allows us to model cancer progression. Here I cover the history and recent advances in reprogramming cancer cells, followed by lessons from cellular reprogramming of normal cells that may apply to cancer. Lastly, I share my perspective on cellular reprogramming for studying epigenetic alterations that have occurred in tumorigenesis, discuss the current limitations, and propose ways to overcome the obstacles in the reprogramming of cancer.

Original languageEnglish (US)
Article number102062
JournalStem Cell Research
Volume49
DOIs
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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