TY - JOUR
T1 - Cellular mechanisms for preservation of timing in central auditory pathways
AU - Trussell, Laurence O.
N1 - Funding Information:
I amg rateful fo S Brenowitz, D Oertel, I Raman and P Smith for their very helpful comments and discussions. Work is my laboratory is supported by grams from the US National Institutes of Health (NS28901 and DC02004).
PY - 1997/8
Y1 - 1997/8
N2 - The faithful preservation of acoustic timing information, as signals are passed from one synaptic level to another, requires a convergence of morphological, biophysical, and biochemical specializations in auditory neurons. Recent studies have focused on the adaptive membrane properties of neurons in the auditory brainstem. These include analyses of neurotransmitter receptors and voltage-gated channels, as well as the mechanisms of transmitter release and its modulation. The molecular composition of the relevant proteins are now being demonstrated, including the glutamate receptor D(flop) (GluR-D(flop)) subunit of AMPA receptors and members of the Kv1 and Kv3 families of potassium channels.
AB - The faithful preservation of acoustic timing information, as signals are passed from one synaptic level to another, requires a convergence of morphological, biophysical, and biochemical specializations in auditory neurons. Recent studies have focused on the adaptive membrane properties of neurons in the auditory brainstem. These include analyses of neurotransmitter receptors and voltage-gated channels, as well as the mechanisms of transmitter release and its modulation. The molecular composition of the relevant proteins are now being demonstrated, including the glutamate receptor D(flop) (GluR-D(flop)) subunit of AMPA receptors and members of the Kv1 and Kv3 families of potassium channels.
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U2 - 10.1016/S0959-4388(97)80027-X
DO - 10.1016/S0959-4388(97)80027-X
M3 - Article
C2 - 9287194
AN - SCOPUS:0031409370
SN - 0959-4388
VL - 7
SP - 487
EP - 492
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -