TY - JOUR
T1 - Cellular Learning Theory
T2 - Theoretical Comment on Cole and McNally (2007)
AU - Lattal, K. Matthew
AU - Bernardi, Rick E.
PY - 2007/10
Y1 - 2007/10
N2 - The idea that learning proceeds as a function of the discrepancy (or error) between expected and obtained outcomes is central to many theories of associative learning. However, remarkably little is known about the neurobiological mechanisms that underlie this learning of predictive errors in fear conditioning, a widely used preparation in studies of cellular and molecular mechanisms of memory. In this issue of Behavioral Neuroscience, S. Cole and G. P. McNally (2007) demonstrate an important dissociation between the establishment and regulation of predictive error at the cellular level. Their findings have added a level of complexity to currently established views of the function of NMDA and opioid receptors in learning and memory. This commentary discusses some of the implications of these findings for theoretical and neurobiological approaches to memory, as well as current thinking about the cellular circuitry involved in reward learning and drug abuse.
AB - The idea that learning proceeds as a function of the discrepancy (or error) between expected and obtained outcomes is central to many theories of associative learning. However, remarkably little is known about the neurobiological mechanisms that underlie this learning of predictive errors in fear conditioning, a widely used preparation in studies of cellular and molecular mechanisms of memory. In this issue of Behavioral Neuroscience, S. Cole and G. P. McNally (2007) demonstrate an important dissociation between the establishment and regulation of predictive error at the cellular level. Their findings have added a level of complexity to currently established views of the function of NMDA and opioid receptors in learning and memory. This commentary discusses some of the implications of these findings for theoretical and neurobiological approaches to memory, as well as current thinking about the cellular circuitry involved in reward learning and drug abuse.
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U2 - 10.1037/0735-7044.121.5.1140
DO - 10.1037/0735-7044.121.5.1140
M3 - Article
C2 - 17907848
AN - SCOPUS:35748985609
SN - 0735-7044
VL - 121
SP - 1140
EP - 1143
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 5
ER -