Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors

Felix P. Eckenstein, Karl Kuzis, Rae Nishi, William R. Woodward, Charles Meshul, Larry Sherman, Gary Ciment

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The distribution in the rat nervous system of acidic and basic fibroblast growth factors (FGFs) was analysed by a combination of biochemical and anatomical methods. Acidic FGF (aFGF) was found to be present exclusively in specific neuronal populations, such as motor neurons and basal forebrain cholinergic neurons. Basic FGF (bFGF) was found in astrocytes and in neurons in hippocampal area CA2. Within labelled astrocytes and CA2-neurons, bFGF was detected in both the cytoplasm and the nucleus. The levels of intracellular bFGF were manipulated by antisense oligonucleotide treatment of cultures of developing neural crest cells. Results indicated that the amount of melanogenesis in the cultures is likely to be regulated by intracellular, possibly nuclear bFGF.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalBiochemical Pharmacology
Volume47
Issue number1
DOIs
StatePublished - Jan 13 1994

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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