Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors

Felix P. Eckenstein, Karl Kuzis, Rae Nishi, William Woodward, Charles Meshul, Lawrence (Larry) Sherman, Gary Ciment

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The distribution in the rat nervous system of acidic and basic fibroblast growth factors (FGFs) was analysed by a combination of biochemical and anatomical methods. Acidic FGF (aFGF) was found to be present exclusively in specific neuronal populations, such as motor neurons and basal forebrain cholinergic neurons. Basic FGF (bFGF) was found in astrocytes and in neurons in hippocampal area CA2. Within labelled astrocytes and CA2-neurons, bFGF was detected in both the cytoplasm and the nucleus. The levels of intracellular bFGF were manipulated by antisense oligonucleotide treatment of cultures of developing neural crest cells. Results indicated that the amount of melanogenesis in the cultures is likely to be regulated by intracellular, possibly nuclear bFGF.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalBiochemical Pharmacology
Volume47
Issue number1
DOIs
StatePublished - Jan 13 1994

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Fibroblast Growth Factor 1
Fibroblast Growth Factor 2
Astrocytes
Neurons
Cholinergic Neurons
Neural Crest
Antisense Oligonucleotides
Motor Neurons
Nervous System
Cytoplasm
Neurology
Cholinergic Agents
Population
Rats
Basal Forebrain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. / Eckenstein, Felix P.; Kuzis, Karl; Nishi, Rae; Woodward, William; Meshul, Charles; Sherman, Lawrence (Larry); Ciment, Gary.

In: Biochemical Pharmacology, Vol. 47, No. 1, 13.01.1994, p. 103-110.

Research output: Contribution to journalArticle

Eckenstein, Felix P. ; Kuzis, Karl ; Nishi, Rae ; Woodward, William ; Meshul, Charles ; Sherman, Lawrence (Larry) ; Ciment, Gary. / Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. In: Biochemical Pharmacology. 1994 ; Vol. 47, No. 1. pp. 103-110.
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