Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors

Felix P. Eckenstein; Karl Kuzis; Rae Nishi; William R. Woodward; Charles Meshul; Larry Sherman; Gary Ciment

doi:10.1016/0006-2952(94)90442-1

Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors

Felix P. Eckenstein, Karl Kuzis, Rae Nishi, William R. Woodward, Charles Meshul, Larry Sherman, Gary Ciment

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Abstract

The distribution in the rat nervous system of acidic and basic fibroblast growth factors (FGFs) was analysed by a combination of biochemical and anatomical methods. Acidic FGF (aFGF) was found to be present exclusively in specific neuronal populations, such as motor neurons and basal forebrain cholinergic neurons. Basic FGF (bFGF) was found in astrocytes and in neurons in hippocampal area CA2. Within labelled astrocytes and CA2-neurons, bFGF was detected in both the cytoplasm and the nucleus. The levels of intracellular bFGF were manipulated by antisense oligonucleotide treatment of cultures of developing neural crest cells. Results indicated that the amount of melanogenesis in the cultures is likely to be regulated by intracellular, possibly nuclear bFGF.

Original language	English (US)
Pages (from-to)	103-110
Number of pages	8
Journal	Biochemical Pharmacology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0006-2952(94)90442-1
State	Published - Jan 13 1994

ASJC Scopus subject areas

Biochemistry
Pharmacology

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title = "Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors",

abstract = "The distribution in the rat nervous system of acidic and basic fibroblast growth factors (FGFs) was analysed by a combination of biochemical and anatomical methods. Acidic FGF (aFGF) was found to be present exclusively in specific neuronal populations, such as motor neurons and basal forebrain cholinergic neurons. Basic FGF (bFGF) was found in astrocytes and in neurons in hippocampal area CA2. Within labelled astrocytes and CA2-neurons, bFGF was detected in both the cytoplasm and the nucleus. The levels of intracellular bFGF were manipulated by antisense oligonucleotide treatment of cultures of developing neural crest cells. Results indicated that the amount of melanogenesis in the cultures is likely to be regulated by intracellular, possibly nuclear bFGF.",

author = "Eckenstein, {Felix P.} and Karl Kuzis and Rae Nishi and Woodward, {William R.} and Charles Meshul and Larry Sherman and Gary Ciment",

note = "Funding Information: Acknowledgements--This work was supported by NIH grants AG07424 and NS17493.",

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AU - Eckenstein, Felix P.

AU - Kuzis, Karl

AU - Nishi, Rae

AU - Woodward, William R.

AU - Meshul, Charles

AU - Sherman, Larry

AU - Ciment, Gary

N1 - Funding Information: Acknowledgements--This work was supported by NIH grants AG07424 and NS17493.

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AB - The distribution in the rat nervous system of acidic and basic fibroblast growth factors (FGFs) was analysed by a combination of biochemical and anatomical methods. Acidic FGF (aFGF) was found to be present exclusively in specific neuronal populations, such as motor neurons and basal forebrain cholinergic neurons. Basic FGF (bFGF) was found in astrocytes and in neurons in hippocampal area CA2. Within labelled astrocytes and CA2-neurons, bFGF was detected in both the cytoplasm and the nucleus. The levels of intracellular bFGF were manipulated by antisense oligonucleotide treatment of cultures of developing neural crest cells. Results indicated that the amount of melanogenesis in the cultures is likely to be regulated by intracellular, possibly nuclear bFGF.

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Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors

Abstract

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