Cellular approaches to understanding the function and regulation of the primate corpus luteum

J. D. Brannian, Richard Stouffer

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Current research suggests that the primate corpus luteum consists of subpopulations of luteal cells that differ in endocrine activity, plus other cell types that likely influence luteal cell function (Fig. 5). In addition to classical hormones, various cell types produce a number of substances that may act locally to control the development, function, and lifespan of the corpus luteum. However, many issues remain unresolved. It is important to determine whether differences between data of various laboratories are due to species differences in luteal cell subpopulations or to different methods and criteria for isolating and classifying cell types. To date, luteal cell subpopulations have been isolated exclusively on the basis of size (i.e., small and large cells). Other techniques, such as fluorescence-activated cell sorting, must be applied to isolate cell types based on their function or endocrine, paracrine, and autocrine regulation. Multiple approaches examining cell types within intact luteal tissue, as well as in preparations of dispersed, highly purified subpopulations, are needed to discern cellular origins, population dynamics, and cell-to-cell interactions. Such information is vital to understanding the processes underlying the formation and regression of the corpus luteum in the normal menstrual cycle or its further differentiation and delayed demise in early pregnancy. As attention turns to the cellular and molecular aspects of luteal function, new parameters may be available for diagnosing and treating luteal dysfunction in spontaneous or artificial cycles. It is conceivable that various types of abnormal luteal phases (e.g., the short luteal phase, the inadequate luteal phase of normal length) are related to defects in specific luteal cell types or lesions in cell types at different times during development. Analyses of luteal tissue and cells from model systems or patients with apparent luteal dysfunction (e.g., women with recurrent early abortion) could provide information on the cause and possible treatment of the disorder. As important endocrine and local roles for estrogen, inhibin-related peptides, or other luteal products are established, it may prove beneficial to provide more than progesterone supplements during luteal dysfunction to promote fertility.

    Original languageEnglish (US)
    Pages (from-to)341-351
    Number of pages11
    JournalSeminars in Reproductive Endocrinology
    Volume9
    Issue number4
    StatePublished - 1991

    Fingerprint

    Corpus Luteum
    Luteal Cells
    Primates
    Luteal Phase
    Luteolysis
    Habitual Abortion
    Inhibins
    Population Dynamics
    Menstrual Cycle
    Cell Communication
    Progesterone
    Fertility
    Flow Cytometry
    Estrogens
    Hormones
    Pregnancy
    Peptides
    Research

    ASJC Scopus subject areas

    • Endocrinology
    • Physiology
    • Endocrinology, Diabetes and Metabolism
    • Reproductive Medicine

    Cite this

    Cellular approaches to understanding the function and regulation of the primate corpus luteum. / Brannian, J. D.; Stouffer, Richard.

    In: Seminars in Reproductive Endocrinology, Vol. 9, No. 4, 1991, p. 341-351.

    Research output: Contribution to journalArticle

    @article{96a6c6c0c503427096f48f4042b3985f,
    title = "Cellular approaches to understanding the function and regulation of the primate corpus luteum",
    abstract = "Current research suggests that the primate corpus luteum consists of subpopulations of luteal cells that differ in endocrine activity, plus other cell types that likely influence luteal cell function (Fig. 5). In addition to classical hormones, various cell types produce a number of substances that may act locally to control the development, function, and lifespan of the corpus luteum. However, many issues remain unresolved. It is important to determine whether differences between data of various laboratories are due to species differences in luteal cell subpopulations or to different methods and criteria for isolating and classifying cell types. To date, luteal cell subpopulations have been isolated exclusively on the basis of size (i.e., small and large cells). Other techniques, such as fluorescence-activated cell sorting, must be applied to isolate cell types based on their function or endocrine, paracrine, and autocrine regulation. Multiple approaches examining cell types within intact luteal tissue, as well as in preparations of dispersed, highly purified subpopulations, are needed to discern cellular origins, population dynamics, and cell-to-cell interactions. Such information is vital to understanding the processes underlying the formation and regression of the corpus luteum in the normal menstrual cycle or its further differentiation and delayed demise in early pregnancy. As attention turns to the cellular and molecular aspects of luteal function, new parameters may be available for diagnosing and treating luteal dysfunction in spontaneous or artificial cycles. It is conceivable that various types of abnormal luteal phases (e.g., the short luteal phase, the inadequate luteal phase of normal length) are related to defects in specific luteal cell types or lesions in cell types at different times during development. Analyses of luteal tissue and cells from model systems or patients with apparent luteal dysfunction (e.g., women with recurrent early abortion) could provide information on the cause and possible treatment of the disorder. As important endocrine and local roles for estrogen, inhibin-related peptides, or other luteal products are established, it may prove beneficial to provide more than progesterone supplements during luteal dysfunction to promote fertility.",
    author = "Brannian, {J. D.} and Richard Stouffer",
    year = "1991",
    language = "English (US)",
    volume = "9",
    pages = "341--351",
    journal = "Seminars in Reproductive Medicine",
    issn = "1526-8004",
    publisher = "Thieme Medical Publishers",
    number = "4",

    }

    TY - JOUR

    T1 - Cellular approaches to understanding the function and regulation of the primate corpus luteum

    AU - Brannian, J. D.

    AU - Stouffer, Richard

    PY - 1991

    Y1 - 1991

    N2 - Current research suggests that the primate corpus luteum consists of subpopulations of luteal cells that differ in endocrine activity, plus other cell types that likely influence luteal cell function (Fig. 5). In addition to classical hormones, various cell types produce a number of substances that may act locally to control the development, function, and lifespan of the corpus luteum. However, many issues remain unresolved. It is important to determine whether differences between data of various laboratories are due to species differences in luteal cell subpopulations or to different methods and criteria for isolating and classifying cell types. To date, luteal cell subpopulations have been isolated exclusively on the basis of size (i.e., small and large cells). Other techniques, such as fluorescence-activated cell sorting, must be applied to isolate cell types based on their function or endocrine, paracrine, and autocrine regulation. Multiple approaches examining cell types within intact luteal tissue, as well as in preparations of dispersed, highly purified subpopulations, are needed to discern cellular origins, population dynamics, and cell-to-cell interactions. Such information is vital to understanding the processes underlying the formation and regression of the corpus luteum in the normal menstrual cycle or its further differentiation and delayed demise in early pregnancy. As attention turns to the cellular and molecular aspects of luteal function, new parameters may be available for diagnosing and treating luteal dysfunction in spontaneous or artificial cycles. It is conceivable that various types of abnormal luteal phases (e.g., the short luteal phase, the inadequate luteal phase of normal length) are related to defects in specific luteal cell types or lesions in cell types at different times during development. Analyses of luteal tissue and cells from model systems or patients with apparent luteal dysfunction (e.g., women with recurrent early abortion) could provide information on the cause and possible treatment of the disorder. As important endocrine and local roles for estrogen, inhibin-related peptides, or other luteal products are established, it may prove beneficial to provide more than progesterone supplements during luteal dysfunction to promote fertility.

    AB - Current research suggests that the primate corpus luteum consists of subpopulations of luteal cells that differ in endocrine activity, plus other cell types that likely influence luteal cell function (Fig. 5). In addition to classical hormones, various cell types produce a number of substances that may act locally to control the development, function, and lifespan of the corpus luteum. However, many issues remain unresolved. It is important to determine whether differences between data of various laboratories are due to species differences in luteal cell subpopulations or to different methods and criteria for isolating and classifying cell types. To date, luteal cell subpopulations have been isolated exclusively on the basis of size (i.e., small and large cells). Other techniques, such as fluorescence-activated cell sorting, must be applied to isolate cell types based on their function or endocrine, paracrine, and autocrine regulation. Multiple approaches examining cell types within intact luteal tissue, as well as in preparations of dispersed, highly purified subpopulations, are needed to discern cellular origins, population dynamics, and cell-to-cell interactions. Such information is vital to understanding the processes underlying the formation and regression of the corpus luteum in the normal menstrual cycle or its further differentiation and delayed demise in early pregnancy. As attention turns to the cellular and molecular aspects of luteal function, new parameters may be available for diagnosing and treating luteal dysfunction in spontaneous or artificial cycles. It is conceivable that various types of abnormal luteal phases (e.g., the short luteal phase, the inadequate luteal phase of normal length) are related to defects in specific luteal cell types or lesions in cell types at different times during development. Analyses of luteal tissue and cells from model systems or patients with apparent luteal dysfunction (e.g., women with recurrent early abortion) could provide information on the cause and possible treatment of the disorder. As important endocrine and local roles for estrogen, inhibin-related peptides, or other luteal products are established, it may prove beneficial to provide more than progesterone supplements during luteal dysfunction to promote fertility.

    UR - http://www.scopus.com/inward/record.url?scp=0026345814&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0026345814&partnerID=8YFLogxK

    M3 - Article

    VL - 9

    SP - 341

    EP - 351

    JO - Seminars in Reproductive Medicine

    JF - Seminars in Reproductive Medicine

    SN - 1526-8004

    IS - 4

    ER -