Cellular and molecular imaging with targeted contrast ultrasound

Carolyn Z. Behm, Jonathan Lindner

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    There is growing interest in the availability of methods for imaging disease at the level of the cellular and/or molecular mediators. Techniques for imaging molecular alterations have been develop for essentially all non-invasive cardiac imaging modalities. Molecular imaging with contrast-enhanced ultrasound relies on the detection of novel site-targeted contrast agents. These microbubbles or nanoparticles are retained within regions of a specific disease process, thereby allowing phenotypic characterization of tissue. Since most of these tracers remain within the intravascular space, the disease processes assessed must be characterized by antigens that are expressed within the vascular compartment. Accordingly, the pathologic states that have been targeted include infammation, ischemia-and tumor-related angiogenesis, and thrombus formation; all of which are mediated in part by molecular events within the vascular space. This review describes: 10 different strategies that have been employed to target ultrasound contrast agents to regions of disease, 2) the unique challenges for imaging targeted ultrasound contrast agents, and 3) some of the early experience imaging molecular events in animal models of disease.

    Original languageEnglish (US)
    Pages (from-to)67-72
    Number of pages6
    JournalUltrasound Quarterly
    Volume22
    Issue number1
    StatePublished - Mar 2006

    Fingerprint

    Molecular Imaging
    Contrast Media
    Blood Vessels
    Animal Disease Models
    Microbubbles
    Nanoparticles
    Ultrasonography
    Thrombosis
    Ischemia
    Antigens
    Neoplasms

    Keywords

    • Angiogenesis
    • Inflammation
    • Microbubbles
    • Molecular imaging

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Cellular and molecular imaging with targeted contrast ultrasound. / Behm, Carolyn Z.; Lindner, Jonathan.

    In: Ultrasound Quarterly, Vol. 22, No. 1, 03.2006, p. 67-72.

    Research output: Contribution to journalArticle

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