The cell surface receptor for ecotropic host-range murine leukemia viruses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter system y+, which was previously characterized by transport assays. Mutational analysis indicates that transporter activity is not necessary for viral reception. Infection of cells with ecotropic retroviruses causes only a partial down-modulation of receptor expression on cell surfaces.
|Original language||English (US)|
|Number of pages||10|
|Journal||Archives of virology. Supplementum|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Immunology and Microbiology(all)