Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.

M. P. Kavanaugh, H. Wang, C. A. Boyd, R. A. North, D. Kabat

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The cell surface receptor for ecotropic host-range murine leukemia viruses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter system y+, which was previously characterized by transport assays. Mutational analysis indicates that transporter activity is not necessary for viral reception. Infection of cells with ecotropic retroviruses causes only a partial down-modulation of receptor expression on cell surfaces.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalArchives of virology. Supplementum
Volume9
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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