Cell-specific, spike timing-dependent plasticities in the dorsal cochlear nucleus

Thanos Tzounopoulos, Yuil Kim, Donata Oertel, Laurence Trussell

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

In the dorsal cochlear nucleus, long-term synaptic plasticity can be induced at the parallel fiber inputs that synapse onto both fusiform principal neurons and cartwheel feedforward inhibitory interneurons. Here we report that in mouse fusiform cells, spikes evoked 5 ms after parallel-fiber excitatory postsynaptic potentials (EPSPs) led to long-term potentiation (LTP), whereas spikes evoked 5 ms before EPSPs led to long-term depression (LTD) of the synapse. The EPSP-spike protocol led to LTD in cartwheel cells, but no synaptic changes resulted from the reverse sequence (spike-EPSP). Plasticity in fusiform and cartwheel cells therefore followed Hebbian and anti-Hebbian learning rules, respectively. Similarly, spikes generated by summing EPSPs from different groups of parallel fibers produced LTP in fusiform cells, and LTD in cartwheel cells. LTD could also be induced in glutamatergic inputs of cartwheel cells by pairing parallel-fiber EPSPs with depolarizing glycinergic PSPs from neighboring cartwheel cells. Thus, synaptic learning rules vary with the postsynaptic cell, and may require the interaction of different transmitter systems.

Original languageEnglish (US)
Pages (from-to)719-725
Number of pages7
JournalNature Neuroscience
Volume7
Issue number7
DOIs
StatePublished - Jul 2004

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Cochlear Nucleus
Excitatory Postsynaptic Potentials
Long-Term Potentiation
Synapses
Learning
Neuronal Plasticity
Interneurons
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cell-specific, spike timing-dependent plasticities in the dorsal cochlear nucleus. / Tzounopoulos, Thanos; Kim, Yuil; Oertel, Donata; Trussell, Laurence.

In: Nature Neuroscience, Vol. 7, No. 7, 07.2004, p. 719-725.

Research output: Contribution to journalArticle

Tzounopoulos, Thanos ; Kim, Yuil ; Oertel, Donata ; Trussell, Laurence. / Cell-specific, spike timing-dependent plasticities in the dorsal cochlear nucleus. In: Nature Neuroscience. 2004 ; Vol. 7, No. 7. pp. 719-725.
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