Abstract
Fourteen patients with various stages of retinoblastoma, five normal volunteers, one patient with breast carcinoma, and five patients with other ocular diseases affecting the retina were tested for cell-mediated immunity by the 125I-iododeoxyuridine cytotoxicity assay against a long-term tissue culture line derived from retinoblastoma and against a control tissue culture line derived from breast carcinoma. Eleven of the 14 patients with retinoblastoma had significantly increased lymphocytoxicity against the retinoblastoma cell line. This cell-mediated immunity may have been directed against retinoblastoma tumor antigens; however, other possibilities included common tissue antigens, virus-coded antigens, and fetal antigens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-8,IN1,9-11 |
| Journal | American journal of ophthalmology |
| Volume | 78 |
| Issue number | 1 |
| State | Published - Jul 1974 |
| Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology