Cell-mediated immunity to a retinoblastoma tissue culture line in patients with retinoblastoma

Devron H. Char, Robert Ellsworth, Alan S. Rabson, Daniel M. Albert, Ronald B. Herberman

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18 Scopus citations

Abstract

Fourteen patients with various stages of retinoblastoma, five normal volunteers, one patient with breast carcinoma, and five patients with other ocular diseases affecting the retina were tested for cell-mediated immunity by the 125I-iododeoxyuridine cytotoxicity assay against a long-term tissue culture line derived from retinoblastoma and against a control tissue culture line derived from breast carcinoma. Eleven of the 14 patients with retinoblastoma had significantly increased lymphocytoxicity against the retinoblastoma cell line. This cell-mediated immunity may have been directed against retinoblastoma tumor antigens; however, other possibilities included common tissue antigens, virus-coded antigens, and fetal antigens.

Original languageEnglish (US)
Pages (from-to)5-8,IN1,9-11
JournalAmerican journal of ophthalmology
Volume78
Issue number1
StatePublished - Jul 1974

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Char, D. H., Ellsworth, R., Rabson, A. S., Albert, D. M., & Herberman, R. B. (1974). Cell-mediated immunity to a retinoblastoma tissue culture line in patients with retinoblastoma. American journal of ophthalmology, 78(1), 5-8,IN1,9-11.