Fourteen patients with various stages of retinoblastoma, five normal volunteers, one patient with breast carcinoma, and five patients with other ocular diseases affecting the retina were tested for cell-mediated immunity by the 125I-iododeoxyuridine cytotoxicity assay against a long-term tissue culture line derived from retinoblastoma and against a control tissue culture line derived from breast carcinoma. Eleven of the 14 patients with retinoblastoma had significantly increased lymphocytoxicity against the retinoblastoma cell line. This cell-mediated immunity may have been directed against retinoblastoma tumor antigens; however, other possibilities included common tissue antigens, virus-coded antigens, and fetal antigens.
|Original language||English (US)|
|Journal||American journal of ophthalmology|
|State||Published - Jul 1974|
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