Cell mediated immunity in experimental allergic encephalomyelitis

cross reactivity between myelin basic protein and mycobacteria antigens

Arthur Vandenbark, D. R. Burger, R. M. Vetto

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to mycobacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against experimental allergic encephalomyelitis, and may have important implications concerning human demyelinating diseases.

Original languageEnglish (US)
Pages (from-to)1233-1236
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume148
Issue number4
StatePublished - 1975

Fingerprint

Myelin Basic Protein
Autoimmune Experimental Encephalomyelitis
Mycobacterium
Cellular Immunity
Guinea Pigs
Antigens
Skin
Demyelinating Diseases
Spinal Cord
Animals
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to mycobacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against experimental allergic encephalomyelitis, and may have important implications concerning human demyelinating diseases.",
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