Cell-Mediated Immunity in Experimental Allergic Encephalomyelitis: Cross Reactivity Between Myelin Basic Protein and Mycobacteria Antigens (38723)

Arthur A. Vandenbark; Denis R. Burger; R. Mark Vetto

doi:10.3181/00379727-148-38723

Cell-Mediated Immunity in Experimental Allergic Encephalomyelitis: Cross Reactivity Between Myelin Basic Protein and Mycobacteria Antigens (38723)

Arthur A. Vandenbark, Denis R. Burger, R. Mark Vetto

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to myco-bacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against EAE, and may have important implications concerning human demyelinating diseases. We are grateful for the assistance of Hatsumi Park and Patricia Finke.

Original language	English (US)
Pages (from-to)	1233-1236
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	148
Issue number	4
DOIs	https://doi.org/10.3181/00379727-148-38723
State	Published - Apr 1975
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-148-38723

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Cell-Mediated Immunity in Experimental Allergic Encephalomyelitis: Cross Reactivity Between Myelin Basic Protein and Mycobacteria Antigens (38723). / Vandenbark, Arthur A.; Burger, Denis R.; Vetto, R. Mark.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 148, No. 4, 04.1975, p. 1233-1236.

Research output: Contribution to journal › Article › peer-review

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abstract = "Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to myco-bacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against EAE, and may have important implications concerning human demyelinating diseases. We are grateful for the assistance of Hatsumi Park and Patricia Finke.",

author = "Vandenbark, {Arthur A.} and Burger, {Denis R.} and Vetto, {R. Mark}",

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Cell-Mediated Immunity in Experimental Allergic Encephalomyelitis: Cross Reactivity Between Myelin Basic Protein and Mycobacteria Antigens (38723)

Abstract

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