TY - JOUR
T1 - Cell-Mediated Immunity in Experimental Allergic Encephalomyelitis
T2 - Cross Reactivity Between Myelin Basic Protein and Mycobacteria Antigens (38723)
AU - Vandenbark, Arthur A.
AU - Burger, Denis R.
AU - Vetto, R. Mark
N1 - Funding Information:
Supported by Research Grant 8958-01 from the Veterans Administration Hospital, Portland, Oregon 97207.
PY - 1975/4
Y1 - 1975/4
N2 - Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to myco-bacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against EAE, and may have important implications concerning human demyelinating diseases. We are grateful for the assistance of Hatsumi Park and Patricia Finke.
AB - Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to myco-bacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against EAE, and may have important implications concerning human demyelinating diseases. We are grateful for the assistance of Hatsumi Park and Patricia Finke.
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U2 - 10.3181/00379727-148-38723
DO - 10.3181/00379727-148-38723
M3 - Article
C2 - 48264
AN - SCOPUS:0016798781
SN - 0037-9727
VL - 148
SP - 1233
EP - 1236
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 4
ER -