Cell-matrix interactions in mammary gland development and breast cancer.

John Muschler, Charles H. Streuli

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The mammary gland is an organ that at once gives life to the young, but at the same time poses one of the greatest threats to the mother. Understanding how the tissue develops and functions is of pressing importance in determining how its control mechanisms break down in breast cancer. Here we argue that the interactions between mammary epithelial cells and their extracellular matrix (ECM) are crucial in the development and function of the tissue. Current strategies for treating breast cancer take advantage of our knowledge of the endocrine regulation of breast development, and the emerging role of stromal-epithelial interactions (Fig. 1). Focusing, in addition, on the microenvironmental influences that arise from cell-matrix interactions will open new opportunities for therapeutic intervention. We suggest that ultimately a three-pronged approach targeting endocrine, growth factor, and cell-matrix interactions will provide the best chance of curing the disease.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume2
Issue number10
StatePublished - Oct 1 2010
Externally publishedYes

Fingerprint

Human Mammary Glands
Cell Communication
Breast
Breast Neoplasms
Tissue
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Epithelial Cells
Curing
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cell-matrix interactions in mammary gland development and breast cancer. / Muschler, John; Streuli, Charles H.

In: Cold Spring Harbor perspectives in biology, Vol. 2, No. 10, 01.10.2010.

Research output: Contribution to journalArticle

@article{826ac735012843c4af079d7df1acb39c,
title = "Cell-matrix interactions in mammary gland development and breast cancer.",
abstract = "The mammary gland is an organ that at once gives life to the young, but at the same time poses one of the greatest threats to the mother. Understanding how the tissue develops and functions is of pressing importance in determining how its control mechanisms break down in breast cancer. Here we argue that the interactions between mammary epithelial cells and their extracellular matrix (ECM) are crucial in the development and function of the tissue. Current strategies for treating breast cancer take advantage of our knowledge of the endocrine regulation of breast development, and the emerging role of stromal-epithelial interactions (Fig. 1). Focusing, in addition, on the microenvironmental influences that arise from cell-matrix interactions will open new opportunities for therapeutic intervention. We suggest that ultimately a three-pronged approach targeting endocrine, growth factor, and cell-matrix interactions will provide the best chance of curing the disease.",
author = "John Muschler and Streuli, {Charles H.}",
year = "2010",
month = "10",
day = "1",
language = "English (US)",
volume = "2",
journal = "Cold Spring Harbor perspectives in biology",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",
number = "10",

}

TY - JOUR

T1 - Cell-matrix interactions in mammary gland development and breast cancer.

AU - Muschler, John

AU - Streuli, Charles H.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - The mammary gland is an organ that at once gives life to the young, but at the same time poses one of the greatest threats to the mother. Understanding how the tissue develops and functions is of pressing importance in determining how its control mechanisms break down in breast cancer. Here we argue that the interactions between mammary epithelial cells and their extracellular matrix (ECM) are crucial in the development and function of the tissue. Current strategies for treating breast cancer take advantage of our knowledge of the endocrine regulation of breast development, and the emerging role of stromal-epithelial interactions (Fig. 1). Focusing, in addition, on the microenvironmental influences that arise from cell-matrix interactions will open new opportunities for therapeutic intervention. We suggest that ultimately a three-pronged approach targeting endocrine, growth factor, and cell-matrix interactions will provide the best chance of curing the disease.

AB - The mammary gland is an organ that at once gives life to the young, but at the same time poses one of the greatest threats to the mother. Understanding how the tissue develops and functions is of pressing importance in determining how its control mechanisms break down in breast cancer. Here we argue that the interactions between mammary epithelial cells and their extracellular matrix (ECM) are crucial in the development and function of the tissue. Current strategies for treating breast cancer take advantage of our knowledge of the endocrine regulation of breast development, and the emerging role of stromal-epithelial interactions (Fig. 1). Focusing, in addition, on the microenvironmental influences that arise from cell-matrix interactions will open new opportunities for therapeutic intervention. We suggest that ultimately a three-pronged approach targeting endocrine, growth factor, and cell-matrix interactions will provide the best chance of curing the disease.

UR - http://www.scopus.com/inward/record.url?scp=79952201972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952201972&partnerID=8YFLogxK

M3 - Article

C2 - 20702598

AN - SCOPUS:79952201972

VL - 2

JO - Cold Spring Harbor perspectives in biology

JF - Cold Spring Harbor perspectives in biology

SN - 1943-0264

IS - 10

ER -