Abstract
Metastatic melanoma is a fatal malignancy which is remarkably resistant to treatment. It is not entirely clear what determines transition from primary local to metastatic melanoma. Recent gene profiling studies shed light onto the complexity of pathogenesis of melanoma progression. An interaction between cell cycle signaling, adhesion pathways and epithelial-mesenchimal transition program appears to be critical in the development of metastatic disease. An isolated deregulation of either of those pathways may not be sufficient to initiate tumor evolution towards an aggressive phenotype. Here we review how they act in concert to make such a transition possible.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 707-714 |
| Number of pages | 8 |
| Journal | Cancer and Metastasis Reviews |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2008 |
| Externally published | Yes |
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Keywords
- Adhesion
- Cell cycle
- Melanoma
- Metastasis
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Cell cycle control and adhesion signaling pathways in the development of metastatic melanoma. / Danilov, Alexey; Danilova, O. V.; Huber, B. T.
In: Cancer and Metastasis Reviews, Vol. 27, No. 4, 12.2008, p. 707-714.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell cycle control and adhesion signaling pathways in the development of metastatic melanoma
AU - Danilov, Alexey
AU - Danilova, O. V.
AU - Huber, B. T.
PY - 2008/12
Y1 - 2008/12
N2 - Metastatic melanoma is a fatal malignancy which is remarkably resistant to treatment. It is not entirely clear what determines transition from primary local to metastatic melanoma. Recent gene profiling studies shed light onto the complexity of pathogenesis of melanoma progression. An interaction between cell cycle signaling, adhesion pathways and epithelial-mesenchimal transition program appears to be critical in the development of metastatic disease. An isolated deregulation of either of those pathways may not be sufficient to initiate tumor evolution towards an aggressive phenotype. Here we review how they act in concert to make such a transition possible.
AB - Metastatic melanoma is a fatal malignancy which is remarkably resistant to treatment. It is not entirely clear what determines transition from primary local to metastatic melanoma. Recent gene profiling studies shed light onto the complexity of pathogenesis of melanoma progression. An interaction between cell cycle signaling, adhesion pathways and epithelial-mesenchimal transition program appears to be critical in the development of metastatic disease. An isolated deregulation of either of those pathways may not be sufficient to initiate tumor evolution towards an aggressive phenotype. Here we review how they act in concert to make such a transition possible.
KW - Adhesion
KW - Cell cycle
KW - Melanoma
KW - Metastasis
UR - http://www.scopus.com/inward/record.url?scp=52549089940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52549089940&partnerID=8YFLogxK
U2 - 10.1007/s10555-008-9159-2
DO - 10.1007/s10555-008-9159-2
M3 - Article
VL - 27
SP - 707
EP - 714
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
SN - 0167-7659
IS - 4
ER -