Cell cycle analysis from computer synthesis of deoxyribonucleic acid histograms

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Abstract

A method is presented for the computer synthesis of deoxyribonucleic acid (DNA) histograms, based on estimates of cell distribution around a life cycle, DNA synthesis rate and instrumentally introduced dispersion. Synthetic histograms are compared with experimental DNA histograms for 2 cell systems; in one, the cell population is in asynchronous exponential growth (steady state), in the other, the cell population is recovering from a block at the G/S phase interface (nonsteady state). The average phase transit times and the associated dispersions are determined, using a DNA histogram synthesis technique, for the nonsteady state population.

Original languageEnglish (US)
Pages (from-to)642-650
Number of pages9
JournalJournal of Histochemistry and Cytochemistry
Volume22
Issue number7
DOIs
StatePublished - Jan 1 1974

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ASJC Scopus subject areas

  • Anatomy
  • Histology

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