Abstract
A method is presented for the computer synthesis of deoxyribonucleic acid (DNA) histograms, based on estimates of cell distribution around a life cycle, DNA synthesis rate and instrumentally introduced dispersion. Synthetic histograms are compared with experimental DNA histograms for 2 cell systems; in one, the cell population is in asynchronous exponential growth (steady state), in the other, the cell population is recovering from a block at the G/S phase interface (nonsteady state). The average phase transit times and the associated dispersions are determined, using a DNA histogram synthesis technique, for the nonsteady state population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 642-650 |
| Number of pages | 9 |
| Journal | Journal of Histochemistry and Cytochemistry |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
ASJC Scopus subject areas
- Anatomy
- Histology