TY - JOUR
T1 - Cell-cell contact, cyclic amp, and gene expression during development of dictyostelium discoideum
AU - Mangiarotti, Giorgio
AU - Bozzaro, Salvatore
AU - Landfear, Scott
AU - Lodisht, Harvey F.
N1 - Funding Information:
Work from the author’s laboratories was supported by grants 79-00839 from the National Science Foundation and GM29897 from the National Institutes of Health to H.F.L. and by a grant from the C.N.R. to G.M. We thank Miriam Boucher for her skill in reading the illegible.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Dictyostelium discoideum exhibits many features of development seen in more complex eukaryotic organisms: specific cell–cell contacts are found; a homogeneous cell population differentiates into discrete cell types; and there is specific cell migration and pattern formation. These morphogenetic changes are accompanied by major changes in the pattern of gene expression. This chapter discusses the transcription of these genes, which is controlled by many of the same factors that affect gene expression in other differentiating systems, in particular, by cell- cell contact and by an extracellular hormone, cyclic AMP. Cell–cell contact in Dictyostelium is essential for stabilizing a large class of regulated mRNAs. cAMP also induces or accelerates at least part of the developmental program and may also induce the cytodifferentiation and segregation of prestalk and prespore cells. cAMP increases the synthesis and the stability of the 2500 mRNA species that are induced at aggregation; addition of this compound to disaggregated cells restores synthesis of these mRNAs.
AB - Dictyostelium discoideum exhibits many features of development seen in more complex eukaryotic organisms: specific cell–cell contacts are found; a homogeneous cell population differentiates into discrete cell types; and there is specific cell migration and pattern formation. These morphogenetic changes are accompanied by major changes in the pattern of gene expression. This chapter discusses the transcription of these genes, which is controlled by many of the same factors that affect gene expression in other differentiating systems, in particular, by cell- cell contact and by an extracellular hormone, cyclic AMP. Cell–cell contact in Dictyostelium is essential for stabilizing a large class of regulated mRNAs. cAMP also induces or accelerates at least part of the developmental program and may also induce the cytodifferentiation and segregation of prestalk and prespore cells. cAMP increases the synthesis and the stability of the 2500 mRNA species that are induced at aggregation; addition of this compound to disaggregated cells restores synthesis of these mRNAs.
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U2 - 10.1016/S0070-2153(08)60581-5
DO - 10.1016/S0070-2153(08)60581-5
M3 - Article
C2 - 6301758
AN - SCOPUS:0020687916
SN - 0070-2153
VL - 18
SP - 117
EP - 154
JO - Current topics in developmental biology
JF - Current topics in developmental biology
IS - C
ER -