Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation

Ihab I. El Hajj, Shahid M. Malik, Hany R. Alwakeel, Obaid S. Shaikh, Eizaburo Sasatomi, Hossam M. Kandil

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury.

Original languageEnglish (US)
Pages (from-to)3937-3939
Number of pages3
JournalWorld Journal of Gastroenterology
Volume15
Issue number31
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Celecoxib
  • Cholestatic hepatitis
  • Liver failure
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology

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