CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease

Judith A. Guzman-Cottrill; Francesca L. Garcia; Stanford T. Shulman; Anne H. Rowley

doi:10.1097/01.inf.0000157224.25722.76

CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease

Judith A. Guzman-Cottrill, Francesca L. Garcia, Stanford T. Shulman, Anne H. Rowley

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Coronary arterial inflammation in acute Kawasaki disease (KD) is characterized by transmural infiltration of CD8 T lymphocytes, suggesting that CD8 T lymphocyte cytotoxic activity may be important in the pathogenesis of coronary arterial damage in acute KD. We performed immunohistochemistry for the cytotoxic proteins perforin and granzyme B on paraffin-embedded, formalin-fixed coronary artery aneurysm tissue from 6 children who died in the acute stage of KD. Neither perforin nor granzyme B was detected in the KD coronary aneurysm wall. We speculate that the etiologic agent of KD interferes with expression of these cytotoxic proteins by CD8 T lymphocytes, prolonging inflammation in the arterial wall and leading to coronary artery aneurysm formation.

Original language	English (US)
Pages (from-to)	382-384
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	24
Issue number	4
DOIs	https://doi.org/10.1097/01.inf.0000157224.25722.76
State	Published - Apr 2005
Externally published	Yes

Keywords

Granzyme B
Kawasaki disease
Perforin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/01.inf.0000157224.25722.76

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title = "CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease",

abstract = "Coronary arterial inflammation in acute Kawasaki disease (KD) is characterized by transmural infiltration of CD8 T lymphocytes, suggesting that CD8 T lymphocyte cytotoxic activity may be important in the pathogenesis of coronary arterial damage in acute KD. We performed immunohistochemistry for the cytotoxic proteins perforin and granzyme B on paraffin-embedded, formalin-fixed coronary artery aneurysm tissue from 6 children who died in the acute stage of KD. Neither perforin nor granzyme B was detected in the KD coronary aneurysm wall. We speculate that the etiologic agent of KD interferes with expression of these cytotoxic proteins by CD8 T lymphocytes, prolonging inflammation in the arterial wall and leading to coronary artery aneurysm formation.",

keywords = "Granzyme B, Kawasaki disease, Perforin",

author = "Guzman-Cottrill, {Judith A.} and Garcia, {Francesca L.} and Shulman, {Stanford T.} and Rowley, {Anne H.}",

year = "2005",

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doi = "10.1097/01.inf.0000157224.25722.76",

language = "English (US)",

volume = "24",

pages = "382--384",

journal = "Pediatric Infectious Disease Journal",

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T1 - CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease

AU - Guzman-Cottrill, Judith A.

AU - Garcia, Francesca L.

AU - Shulman, Stanford T.

AU - Rowley, Anne H.

PY - 2005/4

Y1 - 2005/4

N2 - Coronary arterial inflammation in acute Kawasaki disease (KD) is characterized by transmural infiltration of CD8 T lymphocytes, suggesting that CD8 T lymphocyte cytotoxic activity may be important in the pathogenesis of coronary arterial damage in acute KD. We performed immunohistochemistry for the cytotoxic proteins perforin and granzyme B on paraffin-embedded, formalin-fixed coronary artery aneurysm tissue from 6 children who died in the acute stage of KD. Neither perforin nor granzyme B was detected in the KD coronary aneurysm wall. We speculate that the etiologic agent of KD interferes with expression of these cytotoxic proteins by CD8 T lymphocytes, prolonging inflammation in the arterial wall and leading to coronary artery aneurysm formation.

AB - Coronary arterial inflammation in acute Kawasaki disease (KD) is characterized by transmural infiltration of CD8 T lymphocytes, suggesting that CD8 T lymphocyte cytotoxic activity may be important in the pathogenesis of coronary arterial damage in acute KD. We performed immunohistochemistry for the cytotoxic proteins perforin and granzyme B on paraffin-embedded, formalin-fixed coronary artery aneurysm tissue from 6 children who died in the acute stage of KD. Neither perforin nor granzyme B was detected in the KD coronary aneurysm wall. We speculate that the etiologic agent of KD interferes with expression of these cytotoxic proteins by CD8 T lymphocytes, prolonging inflammation in the arterial wall and leading to coronary artery aneurysm formation.

KW - Granzyme B

KW - Kawasaki disease

KW - Perforin

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CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease

Abstract

Keywords

ASJC Scopus subject areas

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