CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease

Judith Guzman-Cottrill, Francesca L. Garcia, Stanford T. Shulman, Anne H. Rowley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Coronary arterial inflammation in acute Kawasaki disease (KD) is characterized by transmural infiltration of CD8 T lymphocytes, suggesting that CD8 T lymphocyte cytotoxic activity may be important in the pathogenesis of coronary arterial damage in acute KD. We performed immunohistochemistry for the cytotoxic proteins perforin and granzyme B on paraffin-embedded, formalin-fixed coronary artery aneurysm tissue from 6 children who died in the acute stage of KD. Neither perforin nor granzyme B was detected in the KD coronary aneurysm wall. We speculate that the etiologic agent of KD interferes with expression of these cytotoxic proteins by CD8 T lymphocytes, prolonging inflammation in the arterial wall and leading to coronary artery aneurysm formation.

Original languageEnglish (US)
Pages (from-to)382-384
Number of pages3
JournalPediatric Infectious Disease Journal
Volume24
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Coronary Aneurysm
Mucocutaneous Lymph Node Syndrome
Acute Disease
Coronary Vessels
T-Lymphocytes
Arteritis
Proteins
Cytotoxic T-Lymphocytes
Paraffin
Formaldehyde
Immunohistochemistry

Keywords

  • Granzyme B
  • Kawasaki disease
  • Perforin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease. / Guzman-Cottrill, Judith; Garcia, Francesca L.; Shulman, Stanford T.; Rowley, Anne H.

In: Pediatric Infectious Disease Journal, Vol. 24, No. 4, 04.2005, p. 382-384.

Research output: Contribution to journalArticle

Guzman-Cottrill, Judith ; Garcia, Francesca L. ; Shulman, Stanford T. ; Rowley, Anne H. / CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease. In: Pediatric Infectious Disease Journal. 2005 ; Vol. 24, No. 4. pp. 382-384.
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