CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

Xuefang Ren, Kozaburo Akiyoshi, Arthur A. Vandenbark, Patricia D. Hurn, Halina Offner

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalMetabolic brain disease
Volume26
Issue number1
DOIs
StatePublished - Mar 1 2011

Keywords

  • Cerebral ischemia
  • Middle cerebral artery occlusion
  • Stroke
  • T lymphocyte
  • T regulatory cells

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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