CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

Xuefang Ren; Kozaburo Akiyoshi; Arthur A. Vandenbark; Patricia D. Hurn; Halina Offner

doi:10.1007/s11011-010-9226-6

CD4⁺FoxP3⁺ regulatory T-cells in cerebral ischemic stroke

Xuefang Ren, Kozaburo Akiyoshi, Arthur A. Vandenbark, Patricia D. Hurn, Halina Offner

Neurology

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4⁺CD25 ⁺Foxp3⁺ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3^DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

Original language	English (US)
Pages (from-to)	87-90
Number of pages	4
Journal	Metabolic brain disease
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s11011-010-9226-6
State	Published - Mar 2011

Keywords

Cerebral ischemia
Middle cerebral artery occlusion
Stroke
T lymphocyte
T regulatory cells

ASJC Scopus subject areas

Biochemistry
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1007/s11011-010-9226-6

Cite this

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title = "CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke",

abstract = "Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.",

keywords = "Cerebral ischemia, Middle cerebral artery occlusion, Stroke, T lymphocyte, T regulatory cells",

author = "Xuefang Ren and Kozaburo Akiyoshi and Vandenbark, {Arthur A.} and Hurn, {Patricia D.} and Halina Offner",

note = "Funding Information: Acknowledgments The authors wish to thank Dr. Sushmita Sinha, Ms. Sandhya Subramanian and Dr. Suzan Dziennis for helpful discussions and Ms. Eva Niehaus and Heather Hoem for assistance in preparing the manuscript. This work was supported by NIH grant NR03521 and the Biomedical Laboratory R&D Service, Department of Veterans Affairs.",

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AU - Offner, Halina

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