CD44: From adhesion molecules to signalling regulators

Helmut Ponta, Larry Sherman, Peter A. Herrlich

    Research output: Contribution to journalReview article

    1561 Scopus citations

    Abstract

    Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades, The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes - not only by establishing specific transmembrane complexes, but also by organizing signalling cascades through association with the actin cytoskeleton. CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.

    Original languageEnglish (US)
    Pages (from-to)33-45
    Number of pages13
    JournalNature Reviews Molecular Cell Biology
    Volume4
    Issue number1
    DOIs
    StatePublished - Jan 1 2003

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    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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