CD44: From adhesion molecules to signalling regulators

Helmut Ponta, Larry Sherman, Peter A. Herrlich

    Research output: Contribution to journalReview articlepeer-review

    1843 Scopus citations


    Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades, The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes - not only by establishing specific transmembrane complexes, but also by organizing signalling cascades through association with the actin cytoskeleton. CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.

    Original languageEnglish (US)
    Pages (from-to)33-45
    Number of pages13
    JournalNature Reviews Molecular Cell Biology
    Issue number1
    StatePublished - Jan 1 2003

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology


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