CD44

From adhesion molecules to signalling regulators

Helmut Ponta, Lawrence (Larry) Sherman, Peter A. Herrlich

    Research output: Contribution to journalArticle

    1496 Citations (Scopus)

    Abstract

    Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades, The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes - not only by establishing specific transmembrane complexes, but also by organizing signalling cascades through association with the actin cytoskeleton. CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.

    Original languageEnglish (US)
    Pages (from-to)33-45
    Number of pages13
    JournalNature Reviews Molecular Cell Biology
    Volume4
    Issue number1
    DOIs
    StatePublished - Jan 1 2003

    Fingerprint

    Cell Adhesion Molecules
    Actin Cytoskeleton
    Extracellular Matrix
    Cell Differentiation
    Signal Transduction
    Cell Survival
    Glycoproteins
    Ligands
    Growth
    Proteins

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

    Cite this

    CD44 : From adhesion molecules to signalling regulators. / Ponta, Helmut; Sherman, Lawrence (Larry); Herrlich, Peter A.

    In: Nature Reviews Molecular Cell Biology, Vol. 4, No. 1, 01.01.2003, p. 33-45.

    Research output: Contribution to journalArticle

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