CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis

Ezogelin Oflazoglu, Eric Simpson, Rodd Takiguchi, Jon Hanifin, Iqbal S. Grewal, Hans Peter Gerber

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental stimuli, resulting in increased infiltration of inflammatory cells, IgE production and enhanced expression of various co-stimulatory molecules, Th2 cytokines and chemokines. Antigen presenting cells (APCs) are critical for AD disease pathogenesis and interaction between APCs and inflammatory T cells represents an important signal required for induction and maintenance of the inflammatory process. CD40 was shown to be upregulated on inflammatory cells in patients with atopic dermatitis; however the identity of these cells and their correlation with disease severity remained unknown. To address these questions, we determined CD40 expression in skin lesions and on peripheral blood cells from AD patients and identified a positive correlation between the numbers of CD40 positive cells and disease severity. Furthermore, we identified the nature of CD40 positive cells in skin lesions to include CD1a+ and CD11b+ APCs. Finally, a correlation between serum PARC and IgE levels and the numbers of CD40+ cells in AD skin lesions was found. Combined, these findings demonstrate that CD40 is upregulated on APCs, cell types previously shown to contribute to AD disease pathology, and suggest that therapeutic strategies targeting CD40 positive cells may provide benefit to AD patients.

Original languageEnglish (US)
Pages (from-to)527-533
Number of pages7
JournalEuropean Journal of Dermatology
Volume18
Issue number5
DOIs
StatePublished - Sep 2008

Fingerprint

Antigen-Presenting Cells
Atopic Dermatitis
Skin
Immunoglobulin E
CD11b Antigens
Chemokines
Skin Diseases
Blood Cells
Cell Count
Maintenance
Pathology
Cytokines
T-Lymphocytes
Serum

Keywords

  • APCs
  • Atopic dematitis
  • CD1a
  • CD40
  • PARC

ASJC Scopus subject areas

  • Dermatology

Cite this

CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis. / Oflazoglu, Ezogelin; Simpson, Eric; Takiguchi, Rodd; Hanifin, Jon; Grewal, Iqbal S.; Gerber, Hans Peter.

In: European Journal of Dermatology, Vol. 18, No. 5, 09.2008, p. 527-533.

Research output: Contribution to journalArticle

Oflazoglu, Ezogelin ; Simpson, Eric ; Takiguchi, Rodd ; Hanifin, Jon ; Grewal, Iqbal S. ; Gerber, Hans Peter. / CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis. In: European Journal of Dermatology. 2008 ; Vol. 18, No. 5. pp. 527-533.
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