CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

Bruce C. Richardson; Michael R. Liebling; Jerry L. Hudson

doi:10.1016/0090-1229(90)90125-A

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

Bruce C. Richardson, Michael R. Liebling, Jerry L. Hudson

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.

Original language	English (US)
Pages (from-to)	368-381
Number of pages	14
Journal	Clinical Immunology and Immunopathology
Volume	55
Issue number	3
DOIs	https://doi.org/10.1016/0090-1229(90)90125-A
State	Published - Jun 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

Access to Document

10.1016/0090-1229(90)90125-A

Cite this

@article{457251bdc6a24029bade702f7c0feedd,

title = "CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation",

abstract = "The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.",

author = "Richardson, {Bruce C.} and Liebling, {Michael R.} and Hudson, {Jerry L.}",

note = "Funding Information: The authors thank Ms. Laura Gross and Ms. Camille Wilkinson for expert technical assistance, Ms. Ruth Douglas and Michele Thompson for superb secretarial support, and Dr. Joel Depper for reviewing this manuscript. This work was supported by grants from the NIH (AI2552G, AR20557) and the Michigan Chapter of the Arthritis Foundation.",

year = "1990",

month = jun,

doi = "10.1016/0090-1229(90)90125-A",

language = "English (US)",

volume = "55",

pages = "368--381",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

AU - Richardson, Bruce C.

AU - Liebling, Michael R.

AU - Hudson, Jerry L.

N1 - Funding Information: The authors thank Ms. Laura Gross and Ms. Camille Wilkinson for expert technical assistance, Ms. Ruth Douglas and Michele Thompson for superb secretarial support, and Dr. Joel Depper for reviewing this manuscript. This work was supported by grants from the NIH (AI2552G, AR20557) and the Michigan Chapter of the Arthritis Foundation.

PY - 1990/6

Y1 - 1990/6

N2 - The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.

AB - The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.

UR - http://www.scopus.com/inward/record.url?scp=0025281055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025281055&partnerID=8YFLogxK

U2 - 10.1016/0090-1229(90)90125-A

DO - 10.1016/0090-1229(90)90125-A

M3 - Article

C2 - 1692774

AN - SCOPUS:0025281055

SN - 1521-6616

VL - 55

SP - 368

EP - 381

JO - Clinical Immunology

JF - Clinical Immunology

IS - 3

ER -

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this