CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

Bruce C. Richardson, Michael R. Liebling, Jerry L. Hudson

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.

Original languageEnglish (US)
Pages (from-to)368-381
Number of pages14
JournalClinical Immunology and Immunopathology
Volume55
Issue number3
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Fingerprint Dive into the research topics of 'CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation'. Together they form a unique fingerprint.

Cite this