TY - JOUR
T1 - CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation
AU - Richardson, Bruce C.
AU - Liebling, Michael R.
AU - Hudson, Jerry L.
N1 - Funding Information:
The authors thank Ms. Laura Gross and Ms. Camille Wilkinson for expert technical assistance, Ms. Ruth Douglas and Michele Thompson for superb secretarial support, and Dr. Joel Depper for reviewing this manuscript. This work was supported by grants from the NIH (AI2552G, AR20557) and the Michigan Chapter of the Arthritis Foundation.
PY - 1990/6
Y1 - 1990/6
N2 - The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.
AB - The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.
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U2 - 10.1016/0090-1229(90)90125-A
DO - 10.1016/0090-1229(90)90125-A
M3 - Article
C2 - 1692774
AN - SCOPUS:0025281055
SN - 0090-1229
VL - 55
SP - 368
EP - 381
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 3
ER -