Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

Gary Thomas, Joseph Aslan, Laurel Thomas, Pushkar Shinde, Ujwal Shinde, Thomas Simmen

Research output: Contribution to journalComment/debate

8 Citations (Scopus)

Abstract

Vertebrate proteins that fulfill multiple and seemingly disparate functions are increasingly recognized as vital solutions to maintaining homeostasis in the face of the complex cell and tissue physiology of higher metazoans. However, the molecular adaptations that underpin this increased functionality remain elusive. In this Commentary, we review the PACS proteins -which first appeared in lower metazoans as protein traffic modulators and evolved in vertebrates to integrate cytoplasmic protein traffic and interorganellar communication with nuclear gene expression -as examples of protein adaptation 'caught in the act'. Vertebrate PACS-1 and PACS-2 increased their functional density and roles as metabolic switches by acquiring phosphorylation sites and nuclear trafficking signals within disordered regions of the proteins. These findings illustrate one mechanism by which vertebrates accommodate their complex cell physiology with a limited set of proteins. We will also highlight how pathogenic viruses exploit the PACS sorting pathways as well as recent studies on PACS genes with mutations or altered expression that result in diverse diseases. These discoveries suggest that investigation of the evolving PACS protein family provides a rich opportunity for insight into vertebrate cell and organ homeostasis.

Original languageEnglish (US)
Pages (from-to)1865-1876
Number of pages12
JournalJournal of Cell Science
Volume130
Issue number11
DOIs
StatePublished - Jun 1 2017

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Homeostasis
Vertebrates
Proteins
Cell Physiological Phenomena
Communication
Phosphorylation
Viruses
Gene Expression
Mutation
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease. / Thomas, Gary; Aslan, Joseph; Thomas, Laurel; Shinde, Pushkar; Shinde, Ujwal; Simmen, Thomas.

In: Journal of Cell Science, Vol. 130, No. 11, 01.06.2017, p. 1865-1876.

Research output: Contribution to journalComment/debate

Thomas, Gary ; Aslan, Joseph ; Thomas, Laurel ; Shinde, Pushkar ; Shinde, Ujwal ; Simmen, Thomas. / Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease. In: Journal of Cell Science. 2017 ; Vol. 130, No. 11. pp. 1865-1876.
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