Catecholaminergic fiber sprouting in granuloprival coeruleo-cerebellar cultures

Fredrick J. Seil, Kenneth L. Tiekotter, William R. Woodward

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Neonatal mouse coeruleo-cerebellar explants exposed to cytosine arabinoside to destroy granule cell precursors demonstrated sprouting of catecholaminergic fibers after 15 days in vitro. Levels of dopamine in granuloprival coeruleo-cerebellar cultures were more than twice those of control cultures. As granuloprival cerebellar cultures also demonstrate Purkinje cell axon collateral sprouting, the granuloprival coeruleo-cerebellar system, in which there is sprouting of two different neuronal groups, may provide a model to investigate the nature and specificity of the signal or signals that induce axonal sprouting.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalDevelopmental Brain Research
Volume21
Issue number2
DOIs
StatePublished - Aug 1985

Keywords

  • axonal sprouting
  • catecholamine
  • catecholaminergic fiber sprouting
  • coeruleo-cerebellar explant
  • granuloprival cerebellar culture

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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