Casting a wider net: Immunosurveillance by nonclassical MHC molecules

M. Patricia D'Souza, Erin Adams, John D. Altman, Michael E. Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh Hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Frueh, Timothy Gondré-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G. Kasmar, Nina Kunwar, Judith Lavelle, David Lewinsohn, Branch Moody, Louis PickerLakshmi Ramachandra, Nilabh Shastri, Peter Parham, Andrew J. McMichael, Jonathan W. Yewdell

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered "unconventional," in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, "Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens," sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential.

Original languageEnglish (US)
Pages (from-to)e1007567
JournalPLoS pathogens
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Immunologic Monitoring
Major Histocompatibility Complex
T-Lymphocytes
National Institute of Allergy and Infectious Diseases (U.S.)
HLA-G Antigens
Oligopeptides
T-Cell Antigen Receptor
Tuberculosis
Vaccines
HIV
Lipids
Education
Antigens
Peptides
Neoplasms

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

Cite this

D'Souza, M. P., Adams, E., Altman, J. D., Birnbaum, M. E., Boggiano, C., Casorati, G., ... Yewdell, J. W. (2019). Casting a wider net: Immunosurveillance by nonclassical MHC molecules. PLoS pathogens, 15(2), e1007567. https://doi.org/10.1371/journal.ppat.1007567

Casting a wider net : Immunosurveillance by nonclassical MHC molecules. / D'Souza, M. Patricia; Adams, Erin; Altman, John D.; Birnbaum, Michael E.; Boggiano, Cesar; Casorati, Giulia; Chien, Yueh Hsiu; Conley, Anthony; Eckle, Sidonia Barbara Guiomar; Frueh, Klaus; Gondré-Lewis, Timothy; Hassan, Namir; Huang, Huang; Jayashankar, Lakshmi; Kasmar, Anne G.; Kunwar, Nina; Lavelle, Judith; Lewinsohn, David; Moody, Branch; Picker, Louis; Ramachandra, Lakshmi; Shastri, Nilabh; Parham, Peter; McMichael, Andrew J.; Yewdell, Jonathan W.

In: PLoS pathogens, Vol. 15, No. 2, 01.02.2019, p. e1007567.

Research output: Contribution to journalReview article

D'Souza, MP, Adams, E, Altman, JD, Birnbaum, ME, Boggiano, C, Casorati, G, Chien, YH, Conley, A, Eckle, SBG, Frueh, K, Gondré-Lewis, T, Hassan, N, Huang, H, Jayashankar, L, Kasmar, AG, Kunwar, N, Lavelle, J, Lewinsohn, D, Moody, B, Picker, L, Ramachandra, L, Shastri, N, Parham, P, McMichael, AJ & Yewdell, JW 2019, 'Casting a wider net: Immunosurveillance by nonclassical MHC molecules', PLoS pathogens, vol. 15, no. 2, pp. e1007567. https://doi.org/10.1371/journal.ppat.1007567
D'Souza MP, Adams E, Altman JD, Birnbaum ME, Boggiano C, Casorati G et al. Casting a wider net: Immunosurveillance by nonclassical MHC molecules. PLoS pathogens. 2019 Feb 1;15(2):e1007567. https://doi.org/10.1371/journal.ppat.1007567
D'Souza, M. Patricia ; Adams, Erin ; Altman, John D. ; Birnbaum, Michael E. ; Boggiano, Cesar ; Casorati, Giulia ; Chien, Yueh Hsiu ; Conley, Anthony ; Eckle, Sidonia Barbara Guiomar ; Frueh, Klaus ; Gondré-Lewis, Timothy ; Hassan, Namir ; Huang, Huang ; Jayashankar, Lakshmi ; Kasmar, Anne G. ; Kunwar, Nina ; Lavelle, Judith ; Lewinsohn, David ; Moody, Branch ; Picker, Louis ; Ramachandra, Lakshmi ; Shastri, Nilabh ; Parham, Peter ; McMichael, Andrew J. ; Yewdell, Jonathan W. / Casting a wider net : Immunosurveillance by nonclassical MHC molecules. In: PLoS pathogens. 2019 ; Vol. 15, No. 2. pp. e1007567.
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