Abstract
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered "unconventional," in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, "Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens," sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e1007567 |
| Journal | PLoS pathogens |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2019 |
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ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Molecular Biology
- Genetics
- Virology
Cite this
Casting a wider net : Immunosurveillance by nonclassical MHC molecules. / D'Souza, M. Patricia; Adams, Erin; Altman, John D.; Birnbaum, Michael E.; Boggiano, Cesar; Casorati, Giulia; Chien, Yueh Hsiu; Conley, Anthony; Eckle, Sidonia Barbara Guiomar; Frueh, Klaus; Gondré-Lewis, Timothy; Hassan, Namir; Huang, Huang; Jayashankar, Lakshmi; Kasmar, Anne G.; Kunwar, Nina; Lavelle, Judith; Lewinsohn, David; Moody, Branch; Picker, Louis; Ramachandra, Lakshmi; Shastri, Nilabh; Parham, Peter; McMichael, Andrew J.; Yewdell, Jonathan W.
In: PLoS pathogens, Vol. 15, No. 2, 01.02.2019, p. e1007567.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Casting a wider net
T2 - Immunosurveillance by nonclassical MHC molecules
AU - D'Souza, M. Patricia
AU - Adams, Erin
AU - Altman, John D.
AU - Birnbaum, Michael E.
AU - Boggiano, Cesar
AU - Casorati, Giulia
AU - Chien, Yueh Hsiu
AU - Conley, Anthony
AU - Eckle, Sidonia Barbara Guiomar
AU - Frueh, Klaus
AU - Gondré-Lewis, Timothy
AU - Hassan, Namir
AU - Huang, Huang
AU - Jayashankar, Lakshmi
AU - Kasmar, Anne G.
AU - Kunwar, Nina
AU - Lavelle, Judith
AU - Lewinsohn, David
AU - Moody, Branch
AU - Picker, Louis
AU - Ramachandra, Lakshmi
AU - Shastri, Nilabh
AU - Parham, Peter
AU - McMichael, Andrew J.
AU - Yewdell, Jonathan W.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered "unconventional," in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, "Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens," sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential.
AB - Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered "unconventional," in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, "Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens," sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential.
UR - http://www.scopus.com/inward/record.url?scp=85061972206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061972206&partnerID=8YFLogxK
U2 - 10.1371/journal.ppat.1007567
DO - 10.1371/journal.ppat.1007567
M3 - Review article
VL - 15
SP - e1007567
JO - PLoS Pathogens
JF - PLoS Pathogens
SN - 1553-7366
IS - 2
ER -