TY - JOUR
T1 - Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes
AU - von Herrath, Matthias
AU - Pagni, Philippe P.
AU - Grove, Kevin
AU - Christoffersson, Gustaf
AU - Tang-Christensen, Mads
AU - Karlsen, Allan Ertmann
AU - Petersen, Jacob Sten
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/4/2
Y1 - 2019/4/2
N2 - Recent articles have highlighted the lack of reproducibility of data from scientific publications. Here we would argue that a better way to describe and also tackle this matter is to use the term “lack of robustness,” since it points toward potential solutions. Presenting several case reports, we highlight examples with common underlying issues from Novo Nordisk's experience: animal model variability, reagent quality, and inter-lab variability. We discuss means to prevent these issues and argue for increased collaborative work and transparent manuscript revision procedures. Collectively, we believe these measures will help promote a more rapid and efficient self-corrective process in diabetes drug target research.
AB - Recent articles have highlighted the lack of reproducibility of data from scientific publications. Here we would argue that a better way to describe and also tackle this matter is to use the term “lack of robustness,” since it points toward potential solutions. Presenting several case reports, we highlight examples with common underlying issues from Novo Nordisk's experience: animal model variability, reagent quality, and inter-lab variability. We discuss means to prevent these issues and argue for increased collaborative work and transparent manuscript revision procedures. Collectively, we believe these measures will help promote a more rapid and efficient self-corrective process in diabetes drug target research.
UR - http://www.scopus.com/inward/record.url?scp=85063320183&partnerID=8YFLogxK
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U2 - 10.1016/j.cmet.2019.02.004
DO - 10.1016/j.cmet.2019.02.004
M3 - Review article
C2 - 30879984
AN - SCOPUS:85063320183
SN - 1550-4131
VL - 29
SP - 795
EP - 802
JO - Cell Metabolism
JF - Cell Metabolism
IS - 4
ER -