Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes

Matthias von Herrath, Philippe P. Pagni, Kevin Grove, Gustaf Christoffersson, Mads Tang-Christensen, Allan Ertmann Karlsen, Jacob Sten Petersen

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Recent articles have highlighted the lack of reproducibility of data from scientific publications. Here we would argue that a better way to describe and also tackle this matter is to use the term “lack of robustness,” since it points toward potential solutions. Presenting several case reports, we highlight examples with common underlying issues from Novo Nordisk's experience: animal model variability, reagent quality, and inter-lab variability. We discuss means to prevent these issues and argue for increased collaborative work and transparent manuscript revision procedures. Collectively, we believe these measures will help promote a more rapid and efficient self-corrective process in diabetes drug target research.

Original languageEnglish (US)
Pages (from-to)795-802
Number of pages8
JournalCell Metabolism
Volume29
Issue number4
DOIs
StatePublished - Apr 2 2019
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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von Herrath, M., Pagni, P. P., Grove, K., Christoffersson, G., Tang-Christensen, M., Karlsen, A. E., & Petersen, J. S. (2019). Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. Cell Metabolism, 29(4), 795-802. https://doi.org/10.1016/j.cmet.2019.02.004

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. / von Herrath, Matthias; Pagni, Philippe P.; Grove, Kevin; Christoffersson, Gustaf; Tang-Christensen, Mads; Karlsen, Allan Ertmann; Petersen, Jacob Sten.

In: Cell Metabolism, Vol. 29, No. 4, 02.04.2019, p. 795-802.

Research output: Contribution to journalReview article

von Herrath, M, Pagni, PP, Grove, K, Christoffersson, G, Tang-Christensen, M, Karlsen, AE & Petersen, JS 2019, 'Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes', Cell Metabolism, vol. 29, no. 4, pp. 795-802. https://doi.org/10.1016/j.cmet.2019.02.004
von Herrath M, Pagni PP, Grove K, Christoffersson G, Tang-Christensen M, Karlsen AE et al. Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. Cell Metabolism. 2019 Apr 2;29(4):795-802. https://doi.org/10.1016/j.cmet.2019.02.004
von Herrath, Matthias ; Pagni, Philippe P. ; Grove, Kevin ; Christoffersson, Gustaf ; Tang-Christensen, Mads ; Karlsen, Allan Ertmann ; Petersen, Jacob Sten. / Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. In: Cell Metabolism. 2019 ; Vol. 29, No. 4. pp. 795-802.
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