Case Report: Yellow Fever Vaccine-Associated Neurotropic Disease and Associated MRI, EEG, and CSF Findings

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Abstract

Yellow fever vaccine-associated neurotropic disease (YEL-AND) is a rare and serious complication following vaccination with the 17D live attenuated yellow fever vaccine. Cases of YEL-AND have presented as acute inflammatory demyelinating polyneuropathy, acute disseminated encephalomyelitis, and meningoencephalitis. To date, intracranial imaging of the progression and resolution of this disease has been minimally depicted in the literature. We present the case of a 67-year-old woman who developed YEL-AND following vaccination. Her diagnosis was complicated by imaging findings consistent with variant Creutzfeldt Jakob Disease. Her clinical history and the progression of her intracranial imaging is discussed in this case report.

Original languageEnglish (US)
Article number779014
JournalFrontiers in Neurology
Volume12
DOIs
StatePublished - Feb 18 2022
Externally publishedYes

Keywords

  • autoimmune encephalitis
  • Creutzfeldt-Jakob Disease
  • post-infectious parkinsonism
  • vaccine adverse event
  • yellow fever associated neurotropic disease
  • yellow fever vaccine
  • yellow fever virus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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