Cascades of transcription regulation during liver regeneration

Svitlana Kurinna, Michelle Craig Barton

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

An increasing demand for new strategies in cancer prevention and regenerative medicine requires a better understanding of molecular mechanisms that control cell proliferation in tissue-specific manner. Regenerating liver is a unique model allowing use of biochemical, genetic, and engineering tools to uncover molecular mechanisms and improve treatment of hepatic cancers, liver failure, and fibrotic disease. Molecular mechanisms of liver regeneration involve extra- and intracellular factors to activate transcription of genes normally silenced in quiescent liver. While many upstream signaling pathways of the regenerating liver have been extensively studied, our knowledge of the downstream effectors, transcription factors (TFs), remains limited. This review describes consecutive engagement of pre-existing and de novo synthesized TFs, as cascades that regulate expression of growth-related and metabolic genes during liver regeneration after partial hepatectomy in mice. Several previously recognized regulators of regenerating liver are described in the light of recently identified co-activator and co-repressor complexes that interact with primary DNA-binding TFs. Published results of gene expression and chromatin immunoprecipitation analyses, as well as studies of transgenic mouse models, are used to emphasize new potential regulators of transcription during liver regeneration. Finally, a more detailed description of newly identified transcriptional regulators of liver regeneration illustrates the tightly regulated balance of proliferative and metabolic responses to partial hepatectomy.

Original languageEnglish (US)
Pages (from-to)189-197
Number of pages9
JournalInternational Journal of Biochemistry and Cell Biology
Volume43
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Keywords

  • Gene expression
  • Hepatectomy
  • Regeneration
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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