Cardiovascular Health in Turner Syndrome: A Scientific Statement From the American Heart Association

American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Council on Peripheral Vascular Disease

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Girls and women with Turner syndrome face a lifelong struggle with both congenital heart disease and acquired cardiovascular conditions. Bicuspid aortic valve is common, and many have left-sided heart obstructive disease of varying severity, from hypoplastic left-sided heart syndrome to minimal aortic stenosis or coarctation of the aorta. Significant enlargement of the thoracic aorta may progress to catastrophic aortic dissection and rupture. It is becoming increasingly apparent that a variety of other cardiovascular conditions, including early-onset hypertension, ischemic heart disease, and stroke, are the major factors reducing the life span of those with Turner syndrome. The presentations and management of cardiovascular conditions in Turner syndrome differ significantly from the general population. Therefore, an international working group reviewed the available evidence regarding the diagnosis and treatment of cardiovascular diseases in Turner syndrome. It is recognized that the suggestions for clinical practice stated here are only the beginning of a process that must also involve the establishment of quality indicators, structures and processes for implementation, and outcome studies.

Original languageEnglish (US)
Pages (from-to)e000048
JournalCirculation. Genomic and precision medicine
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2018

Keywords

  • AHA Scientific Statements
  • aortic aneurysm
  • genetics
  • heart diseases
  • pregnancy
  • Turner syndrome

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    American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Council on Peripheral Vascular Disease (2018). Cardiovascular Health in Turner Syndrome: A Scientific Statement From the American Heart Association. Circulation. Genomic and precision medicine, 11(10), e000048. https://doi.org/10.1161/HCG.0000000000000048