Cardiovascular events following renal transplantation

Role of traditional and transplant-specific risk factors

A. M. De Mattos, J. Prather, A. J. Olyaei, Y. Shibagaki, D. S. Keith, Motomi (Tomi) Mori, Douglas Norman, Thomas Becker

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Cardiovascular mortality is increased in transplant recipients. However, studies including non-fatal events are critical to assess the burden of disease and to identify novel risk factors. We described the incidence of fatal and non-fatal events, and explored associations and interactions among traditional and transplant-specific risk factors and cardiovascular events (CVE) in a cohort of 922 patients transplanted between 1993 and 1998. One hundred and seventy-six patients experienced 201 CVE (111 cardiac, 48 cerebrovascular, 42 peripheral-vascular). Most CVE were non-fatal. Factors associated with cardiac events were (adjusted hazard ratios) tobacco (3.53; P1 year (1.91; P=0.007), and overweight status (1.68; P=0.04); with cerebrovascular events: diabetes and peritoneal dialysis (11.95; P45 (6.77; P141 μmol/l (3.16; P=0.001), peritoneal dialysis (3.06; P=0.027), and obesity (0.32; P=0.046); with peripheral-vascular events: diabetes (8.48; P45 (2.31; P=0.019), and prior CVE (2.25; P=0.016); with mortality: tobacco and deceased-donor (3.52; P45 (1.81; P=0.002), diabetes (1.76; P=0.002), pulse pressure (1.64; P=0.029), prior CVE (1.52; P=0.04), and dialysis >1 year (1.47; P=0.04). The majority of CVE post-transplant were non-fatal. Previous CVE was strongly associated with CVE post-transplant. Interactions among transplant-specific and traditional risks impacted significantly the incidence of CVE. Modifiable factors such as duration of dialysis, deceased-donor transplantation, and acute rejection should be viewed as cardiovascular risks.

Original languageEnglish (US)
Pages (from-to)757-764
Number of pages8
JournalKidney International
Volume70
Issue number4
DOIs
StatePublished - Aug 28 2006

Fingerprint

Kidney Transplantation
Transplants
Peritoneal Dialysis
Tobacco
Blood Vessels
Dialysis
Tissue Donors
Mortality
Incidence
Graft Rejection
Obesity
Blood Pressure

Keywords

  • Cardiovascular diseases
  • Cytomegalovirus
  • Kidney transplantation
  • Risk factors

ASJC Scopus subject areas

  • Nephrology

Cite this

Cardiovascular events following renal transplantation : Role of traditional and transplant-specific risk factors. / De Mattos, A. M.; Prather, J.; Olyaei, A. J.; Shibagaki, Y.; Keith, D. S.; Mori, Motomi (Tomi); Norman, Douglas; Becker, Thomas.

In: Kidney International, Vol. 70, No. 4, 28.08.2006, p. 757-764.

Research output: Contribution to journalArticle

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