Cardiac resynchronization therapy

A pilot study examining cognitive change in patients before and after treatment

Neha K. Dixit, Lauren D. Vazquez, Natalie J. Cross, Emily A. Kuhl, Eva R. Serber, Adrienne Kovacs, Duane E. Dede, Jamie B. Conti, Samuel F. Sears

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Cardiovascular patients with reduced cardiovascular output and capacity such as those with congestive heart failure (CHF) have demonstrated cognitive-related dysfunction. The use of cardiac resynchronization therapy (CRT) is considered standard care for CHF patients who do not improve despite optimal medical therapy. Cardiac resynchronization therapy may improve neurocognitive and psychosocial functioning in patients by increasing cardiac output and cerebral perfusion. Methods: A total of 20 patients were examined before and 3 months after CRT device implantation, via administration of standard neurocognitive and psychosocial testingmeasures. Results: Significant improvements in neurocognitive measures of attention (Digit Span: t[20]=-2.695 [55.94 ± 9.27-62.31 ± 10.05], P = 0.015) and information processing (Digit Symbol: t[20]=-4.577, P < 0.001; Controlled Oral Word Association Test: t[20]=-3.338, P = 0.004) were demonstrated. Improvements in cardiac-specific quality of life were also significant (Minnesota Living with Heart Failure Questionnaire: t[16]=3.544, P = 0.005 [55.17 ± 18.23-36.75 ± 18.00]; The Left Ventricular Dysfunction Questionnaire: t[16]=3.544, P = 0.003 [63.43 ± 23.35-43.29 ± 21.62]). Conclusion: These results represent clinically significant, qualitative, and quantitative cognitive functional benefits for patients from a neurocognitive and psychosocial perspective. Results suggest that biventricular pacing improves cardiovascular outcome and psychosocial functioning in patients with CHF. The future investigation of a larger samplewould be beneficial in establishing the depth and breadth of this improvement.

Original languageEnglish (US)
Pages (from-to)84-88
Number of pages5
JournalClinical Cardiology
Volume33
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Cardiac Resynchronization Therapy
Heart Failure
Therapeutics
Word Association Tests
Cardiac Resynchronization Therapy Devices
Left Ventricular Dysfunction
Automatic Data Processing
Cardiac Output
Perfusion
Quality of Life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac resynchronization therapy : A pilot study examining cognitive change in patients before and after treatment. / Dixit, Neha K.; Vazquez, Lauren D.; Cross, Natalie J.; Kuhl, Emily A.; Serber, Eva R.; Kovacs, Adrienne; Dede, Duane E.; Conti, Jamie B.; Sears, Samuel F.

In: Clinical Cardiology, Vol. 33, No. 2, 01.02.2010, p. 84-88.

Research output: Contribution to journalArticle

Dixit, NK, Vazquez, LD, Cross, NJ, Kuhl, EA, Serber, ER, Kovacs, A, Dede, DE, Conti, JB & Sears, SF 2010, 'Cardiac resynchronization therapy: A pilot study examining cognitive change in patients before and after treatment', Clinical Cardiology, vol. 33, no. 2, pp. 84-88. https://doi.org/10.1002/clc.20710
Dixit, Neha K. ; Vazquez, Lauren D. ; Cross, Natalie J. ; Kuhl, Emily A. ; Serber, Eva R. ; Kovacs, Adrienne ; Dede, Duane E. ; Conti, Jamie B. ; Sears, Samuel F. / Cardiac resynchronization therapy : A pilot study examining cognitive change in patients before and after treatment. In: Clinical Cardiology. 2010 ; Vol. 33, No. 2. pp. 84-88.
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AB - Background: Cardiovascular patients with reduced cardiovascular output and capacity such as those with congestive heart failure (CHF) have demonstrated cognitive-related dysfunction. The use of cardiac resynchronization therapy (CRT) is considered standard care for CHF patients who do not improve despite optimal medical therapy. Cardiac resynchronization therapy may improve neurocognitive and psychosocial functioning in patients by increasing cardiac output and cerebral perfusion. Methods: A total of 20 patients were examined before and 3 months after CRT device implantation, via administration of standard neurocognitive and psychosocial testingmeasures. Results: Significant improvements in neurocognitive measures of attention (Digit Span: t[20]=-2.695 [55.94 ± 9.27-62.31 ± 10.05], P = 0.015) and information processing (Digit Symbol: t[20]=-4.577, P < 0.001; Controlled Oral Word Association Test: t[20]=-3.338, P = 0.004) were demonstrated. Improvements in cardiac-specific quality of life were also significant (Minnesota Living with Heart Failure Questionnaire: t[16]=3.544, P = 0.005 [55.17 ± 18.23-36.75 ± 18.00]; The Left Ventricular Dysfunction Questionnaire: t[16]=3.544, P = 0.003 [63.43 ± 23.35-43.29 ± 21.62]). Conclusion: These results represent clinically significant, qualitative, and quantitative cognitive functional benefits for patients from a neurocognitive and psychosocial perspective. Results suggest that biventricular pacing improves cardiovascular outcome and psychosocial functioning in patients with CHF. The future investigation of a larger samplewould be beneficial in establishing the depth and breadth of this improvement.

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