Cardiac receptor physiology and imaging: An update

Grace P. Chen, Ramin Tabibiazar, Kelley R. Branch, Jeanne Link, James H. Caldwell

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Understanding cardiac receptor physiology is crucial to the study of cardiovascular diseases. The availability of noninvasive imaging technology in studying cardiac receptors has greatly expanded our knowledge of their roles in the pathogenesis of several cardiac disorders such as ischemia and heart failure. The dynamic nature imaging "physiology" rather than anatomy often requires precise imaging protocols and complex mathematical modeling. The use of radiolabeled ligands adds the additional complications of radiation safety and radiopharmaceutical synthesis. Successful utilization of this technology must involve collaborative efforts of cardiologists, radiologists, radiochemists, physicists, mathematicians, technologists, and of course, referring physicians. Cardiac receptor imaging offers, in return, only tremendous opportunities for scientific discovery in physiology and pathophysiology, but also opportunities for clinical decision making. Imaging is a powerful tool for following the patients' responses to therapy and for predicting prognosis and dictating treatment. Much more effort is still needed to develop radiopharmaceutical agents for the various receptors and parts of receptor systems that cannot be imaged currently. More research needs to be done to expand this technology for wider clinical application.

Original languageEnglish (US)
Pages (from-to)714-730
Number of pages17
JournalJournal of Nuclear Cardiology
Volume12
Issue number6
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Radiopharmaceuticals
Technology
Anatomy
Cardiovascular Diseases
Ischemia
Heart Failure
Radiation
Ligands
Physicians
Safety
Therapeutics
Research
Clinical Decision-Making
Radiologists
Cardiologists

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chen, G. P., Tabibiazar, R., Branch, K. R., Link, J., & Caldwell, J. H. (2005). Cardiac receptor physiology and imaging: An update. Journal of Nuclear Cardiology, 12(6), 714-730. https://doi.org/10.1016/j.nuclcard.2005.09.008

Cardiac receptor physiology and imaging : An update. / Chen, Grace P.; Tabibiazar, Ramin; Branch, Kelley R.; Link, Jeanne; Caldwell, James H.

In: Journal of Nuclear Cardiology, Vol. 12, No. 6, 11.2005, p. 714-730.

Research output: Contribution to journalArticle

Chen, GP, Tabibiazar, R, Branch, KR, Link, J & Caldwell, JH 2005, 'Cardiac receptor physiology and imaging: An update', Journal of Nuclear Cardiology, vol. 12, no. 6, pp. 714-730. https://doi.org/10.1016/j.nuclcard.2005.09.008
Chen, Grace P. ; Tabibiazar, Ramin ; Branch, Kelley R. ; Link, Jeanne ; Caldwell, James H. / Cardiac receptor physiology and imaging : An update. In: Journal of Nuclear Cardiology. 2005 ; Vol. 12, No. 6. pp. 714-730.
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