Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department

Ricardo C. Cury, Khalid Shash, John T. Nagurney, Guido Rosito, Michael Shapiro, Cesar H. Nomura, Suhny Abbara, Fabian Bamberg, Maros Ferencik, Ehud J. Schmidt, David F. Brown, Udo Hoffmann, Thomas J. Brady

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

Background - Cardiac magnetic resonance (CMR) imaging permits early triage of patients presenting to the emergency department with acute chest pain but has been limited by the inability to differentiate new from old myocardial infarction. Our objective was to evaluate a CMR protocol that includes T2-weighted imaging and assessment of left ventricular wall thickness in detecting patients with acute coronary syndrome in the emergency department. Methods and Results - In this prospective cohort observational study, we enrolled patients presenting to the emergency department with acute chest pain, negative cardiac biomarkers, and no ECG changes indicative of acute ischemia. The CMR protocol consisted of T2-weighted imaging, first-pass perfusion, cine function, delayed-enhancement magnetic resonance imaging, and assessment of left ventricular wall thickness. The clinical outcome (acute coronary syndrome) was defined by review of clinical charts by a consensus panel that used American Heart Association/American College of Cardiology guidelines. Among 62 patients, 13 developed acute coronary syndrome during the index hospitalization. The mean CMR time was 32 ±8 minutes. The new CMR protocol (with the addition of T2-weighted and left ventricular wall thickness) increased the specificity, positive predictive value, and overall accuracy from 84% to 96%, 55% to 85%, and 84% to 93%, respectively, compared with the conventional CMR protocol (cine, perfusion, and delayed-enhancement magnetic resonance imaging). Moreover, in a logistic regression analysis that contained information on clinical risk assessment (c-statistic=0.695) and traditional cardiac risk factors (c-statistic=0.771), the new CMR protocol significantly improved the c-statistic to 0.958 (P

Original languageEnglish (US)
Pages (from-to)837-844
Number of pages8
JournalCirculation
Volume118
Issue number8
DOIs
StatePublished - Aug 19 2008
Externally publishedYes

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Acute Coronary Syndrome
Hospital Emergency Service
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Acute Pain
Chest Pain
Perfusion
Triage
Observational Studies
Electrocardiography
Hospitalization
Cohort Studies
Ischemia
Biomarkers
Logistic Models
Myocardial Infarction
Regression Analysis
Guidelines

Keywords

  • Angina
  • Diagnosis
  • Magnetic resonance imaging
  • Myocardial infarction

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. / Cury, Ricardo C.; Shash, Khalid; Nagurney, John T.; Rosito, Guido; Shapiro, Michael; Nomura, Cesar H.; Abbara, Suhny; Bamberg, Fabian; Ferencik, Maros; Schmidt, Ehud J.; Brown, David F.; Hoffmann, Udo; Brady, Thomas J.

In: Circulation, Vol. 118, No. 8, 19.08.2008, p. 837-844.

Research output: Contribution to journalArticle

Cury, RC, Shash, K, Nagurney, JT, Rosito, G, Shapiro, M, Nomura, CH, Abbara, S, Bamberg, F, Ferencik, M, Schmidt, EJ, Brown, DF, Hoffmann, U & Brady, TJ 2008, 'Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department', Circulation, vol. 118, no. 8, pp. 837-844. https://doi.org/10.1161/CIRCULATIONAHA.107.740597
Cury, Ricardo C. ; Shash, Khalid ; Nagurney, John T. ; Rosito, Guido ; Shapiro, Michael ; Nomura, Cesar H. ; Abbara, Suhny ; Bamberg, Fabian ; Ferencik, Maros ; Schmidt, Ehud J. ; Brown, David F. ; Hoffmann, Udo ; Brady, Thomas J. / Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. In: Circulation. 2008 ; Vol. 118, No. 8. pp. 837-844.
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AU - Cury, Ricardo C.

AU - Shash, Khalid

AU - Nagurney, John T.

AU - Rosito, Guido

AU - Shapiro, Michael

AU - Nomura, Cesar H.

AU - Abbara, Suhny

AU - Bamberg, Fabian

AU - Ferencik, Maros

AU - Schmidt, Ehud J.

AU - Brown, David F.

AU - Hoffmann, Udo

AU - Brady, Thomas J.

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N2 - Background - Cardiac magnetic resonance (CMR) imaging permits early triage of patients presenting to the emergency department with acute chest pain but has been limited by the inability to differentiate new from old myocardial infarction. Our objective was to evaluate a CMR protocol that includes T2-weighted imaging and assessment of left ventricular wall thickness in detecting patients with acute coronary syndrome in the emergency department. Methods and Results - In this prospective cohort observational study, we enrolled patients presenting to the emergency department with acute chest pain, negative cardiac biomarkers, and no ECG changes indicative of acute ischemia. The CMR protocol consisted of T2-weighted imaging, first-pass perfusion, cine function, delayed-enhancement magnetic resonance imaging, and assessment of left ventricular wall thickness. The clinical outcome (acute coronary syndrome) was defined by review of clinical charts by a consensus panel that used American Heart Association/American College of Cardiology guidelines. Among 62 patients, 13 developed acute coronary syndrome during the index hospitalization. The mean CMR time was 32 ±8 minutes. The new CMR protocol (with the addition of T2-weighted and left ventricular wall thickness) increased the specificity, positive predictive value, and overall accuracy from 84% to 96%, 55% to 85%, and 84% to 93%, respectively, compared with the conventional CMR protocol (cine, perfusion, and delayed-enhancement magnetic resonance imaging). Moreover, in a logistic regression analysis that contained information on clinical risk assessment (c-statistic=0.695) and traditional cardiac risk factors (c-statistic=0.771), the new CMR protocol significantly improved the c-statistic to 0.958 (P

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KW - Angina

KW - Diagnosis

KW - Magnetic resonance imaging

KW - Myocardial infarction

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