Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine

S. Krakowka, R. G. Olsen, M. K. Axthelm, J. Rice, K. Winters

    Research output: Contribution to journalArticle

    35 Scopus citations

    Abstract

    Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza viruses and Leptospira canicola-icterohemorrhagiae bacterin) vaccine 3 days prior to oral inoculation with canine paravirus (CPV). Group B dogs received CPV alone. Group C dogs received 1 dose of vaccine only. In none of the 9 CPV-inoculated dogs did clinical signs of CPV infection develop, although high serum antibody titers for CPV developed in all of them. However, in 2 of the 5 CPV-inoculated vaccinates, canine distemper virus encephalomyelitis subsequently developed. The results suggested that CPV exerts an immunomodulating effect on canine immune responses and may be responsible for vaccination failures in dogs.

    Original languageEnglish (US)
    Pages (from-to)137-139
    Number of pages3
    JournalJournal of the American Veterinary Medical Association
    Volume180
    Issue number2
    StatePublished - Nov 3 1982

    ASJC Scopus subject areas

    • veterinary(all)

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