Abstract
Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza viruses and Leptospira canicola-icterohemorrhagiae bacterin) vaccine 3 days prior to oral inoculation with canine paravirus (CPV). Group B dogs received CPV alone. Group C dogs received 1 dose of vaccine only. In none of the 9 CPV-inoculated dogs did clinical signs of CPV infection develop, although high serum antibody titers for CPV developed in all of them. However, in 2 of the 5 CPV-inoculated vaccinates, canine distemper virus encephalomyelitis subsequently developed. The results suggested that CPV exerts an immunomodulating effect on canine immune responses and may be responsible for vaccination failures in dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-139 |
| Number of pages | 3 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 180 |
| Issue number | 2 |
| State | Published - 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Veterinary