Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance

Monish Ram Makena, Alok Ranjan, Vani Thirumala, Arubala Reddy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the tumor. CSCs also have been shown to be involved in fundamental processes of cell proliferation and metastatic dissemination. CSCs are generally resistant to chemotherapy and radiotherapy, a subset of remaining CSCs after therapy can survive and promote cancer relapse and resistance to therapies. Understanding the biological characteristics of CSCs, the pathways leading to their sustainability and proliferation, and the CSCs role in drug resistance is crucial for establishing novel tumor diagnostic and therapeutic strategies. In this review, we address the pathways that regulate CSCs, the role of CSCs in the resistance to therapy, and strategies to overcome therapeutic resistance.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Neoplastic Stem Cells
Therapeutics
Neoplasms
Cell- and Tissue-Based Therapy
Drug Resistance
Radiotherapy
Stem Cells
Cell Proliferation
Recurrence
Drug Therapy

Keywords

  • Cancer stem cells
  • Immune-modulation
  • Pathways affecting stem cells
  • Radio- and chemoresistance

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Cancer stem cells : Road to therapeutic resistance and strategies to overcome resistance. / Makena, Monish Ram; Ranjan, Alok; Thirumala, Vani; Reddy, Arubala.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 01.01.2018.

Research output: Contribution to journalArticle

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