Cancer stem cells in head and neck squamous cell carcinoma

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discuss the therapeutic implications and future directions of this field.

Original languageEnglish (US)
Article number762780
JournalJournal of Oncology
DOIs
StatePublished - 2011

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Neoplastic Stem Cells
Neoplasms
Disease Progression
Carcinoma, squamous cell of head and neck
Neoplasm Metastasis
Growth
Population

ASJC Scopus subject areas

  • Oncology

Cite this

Cancer stem cells in head and neck squamous cell carcinoma. / Wong, Melissa; Monroe, Marcus M.; Anderson, Eric; Clayburgh, Daniel.

In: Journal of Oncology, 2011.

Research output: Contribution to journalArticle

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