Cancer Microenvironments as Therapeutic Targets

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The microenvironment of soLid tumors is a complex amalgam of soluble and insoluble molecules and cells that together constitute an indispensable regulator of tumor growth. Among several questions confronting tumor biologists today are (i) identification of nonparenchymal cells affecting cancer development and progression, (ii) determining how stromal cells regulate patient outcome, and (iii) determining the identity of critical molecular pathways in tumor microenvironment that regulate neoplastic progression. To address these questions, the molecular and cellular architecture of neoplastic tissue must be evaluated to identify functionally significant molecules to target for anticancer therapy. This article focuses on the major subtypes of host cells commonly found in tumor stroma and discusses tractable approaches to target them for anticancer therapy.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages412-422
Number of pages11
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - Jan 1 2014

Fingerprint

Tumor Microenvironment
Neoplasms
Critical Pathways
Therapeutics
Stromal Cells
Growth

Keywords

  • Angiogenesis
  • Cancer
  • Chemoresistance
  • Chemotherapy
  • Extracellular matrix
  • Inflammation
  • Macrophages
  • Microenvironment
  • Myeloid cells
  • Stroma
  • Tumor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kumar, S., & Coussens, L. (2014). Cancer Microenvironments as Therapeutic Targets. In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (pp. 412-422). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386456-7.01909-2

Cancer Microenvironments as Therapeutic Targets. / Kumar, Sushil; Coussens, Lisa.

Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., 2014. p. 412-422.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kumar, S & Coussens, L 2014, Cancer Microenvironments as Therapeutic Targets. in Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., pp. 412-422. https://doi.org/10.1016/B978-0-12-386456-7.01909-2
Kumar S, Coussens L. Cancer Microenvironments as Therapeutic Targets. In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc. 2014. p. 412-422 https://doi.org/10.1016/B978-0-12-386456-7.01909-2
Kumar, Sushil ; Coussens, Lisa. / Cancer Microenvironments as Therapeutic Targets. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., 2014. pp. 412-422
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