Cancer dormancy: Isolation and characterization of dormant lymphoma cells

Eitan Yefenof, Louis Picker, Richard H. Scheuermann, Thomas F. Tucker, Ellen S. Vitetta, Jonathan W. Uhr

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

"Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL1) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.

Original languageEnglish (US)
Pages (from-to)1829-1833
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number5
Publication statusPublished - Mar 1 1993
Externally publishedYes

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ASJC Scopus subject areas

  • General
  • Genetics

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