TY - JOUR
T1 - Cancer chemotherapy-related symptoms
T2 - Evidence to suggest a role for proinflammatory cytokines
AU - Wood, Lisa J.
AU - Nail, Lillian M.
AU - Gilster, April
AU - Winters, Kerri A.
AU - Elsea, Collin R.
PY - 2006
Y1 - 2006
N2 - Purpose/Objectives: To provide an overview of the evidence that supports a role for the proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in the etiology of cancer chemotherapy-related symptoms. Data Sources: Electronic nursing, psychology, and medicine databases; online meeting abstracts; and personal experimental observations. Data Synthesis: Substantial evidence implicates the proinflammatory cytokines IL-1β, TNF-α, and IL-6 in the etiology of chemotherapy-related anorexia, cachexia, anemia, pain, sleep disturbance, fatigue, and depression. Conclusions: Further investigation into the role of these cytokines in the genesis of chemotherapy-related symptoms is warranted. The development of appropriate animal models likely will be key to understanding the relationship among cancer chemotherapy, proinflammatory cytokines, and symptoms. Implications for Nursing: Nurses traditionally have been leaders in symptom management. The symptoms experienced by patients undergoing chemotherapy have a profound negative impact on quality of life and patients' ability to receive prescribed treatments. An understanding of potential mechanisms underlying the physiologic and behavioral consequences of chemotherapy administration will aid nurses in the development of interventions to effectively manage chemotherapy-related symptoms.
AB - Purpose/Objectives: To provide an overview of the evidence that supports a role for the proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in the etiology of cancer chemotherapy-related symptoms. Data Sources: Electronic nursing, psychology, and medicine databases; online meeting abstracts; and personal experimental observations. Data Synthesis: Substantial evidence implicates the proinflammatory cytokines IL-1β, TNF-α, and IL-6 in the etiology of chemotherapy-related anorexia, cachexia, anemia, pain, sleep disturbance, fatigue, and depression. Conclusions: Further investigation into the role of these cytokines in the genesis of chemotherapy-related symptoms is warranted. The development of appropriate animal models likely will be key to understanding the relationship among cancer chemotherapy, proinflammatory cytokines, and symptoms. Implications for Nursing: Nurses traditionally have been leaders in symptom management. The symptoms experienced by patients undergoing chemotherapy have a profound negative impact on quality of life and patients' ability to receive prescribed treatments. An understanding of potential mechanisms underlying the physiologic and behavioral consequences of chemotherapy administration will aid nurses in the development of interventions to effectively manage chemotherapy-related symptoms.
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U2 - 10.1188/06.ONF.535-542
DO - 10.1188/06.ONF.535-542
M3 - Review article
C2 - 16676010
AN - SCOPUS:33746196786
SN - 0190-535X
VL - 33
SP - 535
EP - 542
JO - Oncology nursing forum
JF - Oncology nursing forum
IS - 3
ER -