Can vitamin D delay the progression of ALS?

Chafic Karam, Stephen N. Scelsa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The pathogenesis of amyotrophic lateral sclerosis (ALS) is multifactorial and a treatment targeting only one aspect of the disease is unlikely to be beneficial. Vitamin D is safe and may delay progression of ALS by acting on several aspects of the disease. In this article we explore how vitamin D may promote VGEF, IGF-1 and axonal regeneration delaying ALS progression. In addition, we discuss how vitamin D may increase calcium binding protein in motor neuron cells conferring a greater resistance to the underlying disease process, as seen in the oculomotor nerve and Onuf's nucleus. Finally, we discuss vitamin D immunomodulator role, decreasing the reactive gliosis in ALS.

Original languageEnglish (US)
Pages (from-to)643-645
Number of pages3
JournalMedical Hypotheses
Volume76
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Amyotrophic Lateral Sclerosis
Vitamin D
Oculomotor Nerve
Calcium-Binding Proteins
Gliosis
Immunologic Factors
Motor Neurons
Insulin-Like Growth Factor I
Regeneration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Can vitamin D delay the progression of ALS? / Karam, Chafic; Scelsa, Stephen N.

In: Medical Hypotheses, Vol. 76, No. 5, 05.2011, p. 643-645.

Research output: Contribution to journalArticle

Karam, Chafic ; Scelsa, Stephen N. / Can vitamin D delay the progression of ALS?. In: Medical Hypotheses. 2011 ; Vol. 76, No. 5. pp. 643-645.
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