Abstract
Objective: The objective was to explore whether 3-T magnetic resonance imaging (MRI) can identify low-risk ductal carcinoma in situ (DCIS). Methods: Dynamic contrast-enhanced and diffusion-weighted (DWI) MRI features of 36 DCIS lesions [8 low risk, Van Nuys Pathologic Classification (VNPC) 1; 28 high risk, VNPC 2/3] were reviewed. An MRI model that best identified low-risk DCIS was determined using multivariate logistic regression. Results: Low-risk DCIS exhibited different DWI properties [i.e., higher contrast-to-noise ratio (P=.02) and lower normalized apparent diffusion coefficients (P=.04)] than high-risk DCIS. A model combining these DWI features provided best performance (area under receiver operating characteristic curve =0.86). Conclusions: DWI may help identify DCIS lesions requiring less therapy.
Original language | English (US) |
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Pages (from-to) | 125-129 |
Number of pages | 5 |
Journal | Clinical Imaging |
Volume | 40 |
Issue number | 1 |
DOIs | |
State | Published - Jun 30 2015 |
Externally published | Yes |
Keywords
- Biomarker
- Diffusion-weighted imaging
- Ductal carcinoma in situ
- MRI
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging