Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ?

Habib Rahbar, Sana Parsian, Diana L. Lam, Brian N. Dontchos, Nicole K. Andeen, Mara H. Rendi, Constance D. Lehman, Savannah C. Partridge

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: The objective was to explore whether 3-T magnetic resonance imaging (MRI) can identify low-risk ductal carcinoma in situ (DCIS). Methods: Dynamic contrast-enhanced and diffusion-weighted (DWI) MRI features of 36 DCIS lesions [8 low risk, Van Nuys Pathologic Classification (VNPC) 1; 28 high risk, VNPC 2/3] were reviewed. An MRI model that best identified low-risk DCIS was determined using multivariate logistic regression. Results: Low-risk DCIS exhibited different DWI properties [i.e., higher contrast-to-noise ratio (P=.02) and lower normalized apparent diffusion coefficients (P=.04)] than high-risk DCIS. A model combining these DWI features provided best performance (area under receiver operating characteristic curve =0.86). Conclusions: DWI may help identify DCIS lesions requiring less therapy.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalClinical Imaging
Issue number1
StatePublished - Jun 30 2015
Externally publishedYes


  • Biomarker
  • Diffusion-weighted imaging
  • Ductal carcinoma in situ
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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