Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ?

Habib Rahbar, Sana Parsian, Diana L. Lam, Brian N. Dontchos, Nicole Andeen, Mara H. Rendi, Constance D. Lehman, Savannah C. Partridge

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The objective was to explore whether 3-T magnetic resonance imaging (MRI) can identify low-risk ductal carcinoma in situ (DCIS). Methods: Dynamic contrast-enhanced and diffusion-weighted (DWI) MRI features of 36 DCIS lesions [8 low risk, Van Nuys Pathologic Classification (VNPC) 1; 28 high risk, VNPC 2/3] were reviewed. An MRI model that best identified low-risk DCIS was determined using multivariate logistic regression. Results: Low-risk DCIS exhibited different DWI properties [i.e., higher contrast-to-noise ratio (P=.02) and lower normalized apparent diffusion coefficients (P=.04)] than high-risk DCIS. A model combining these DWI features provided best performance (area under receiver operating characteristic curve =0.86). Conclusions: DWI may help identify DCIS lesions requiring less therapy.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalClinical Imaging
Volume40
Issue number1
DOIs
StatePublished - Jun 30 2015
Externally publishedYes

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Carcinoma, Intraductal, Noninfiltrating
Biomarkers
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
ROC Curve
Noise
Logistic Models

Keywords

  • Biomarker
  • Diffusion-weighted imaging
  • Ductal carcinoma in situ
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Rahbar, H., Parsian, S., Lam, D. L., Dontchos, B. N., Andeen, N., Rendi, M. H., ... Partridge, S. C. (2015). Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ? Clinical Imaging, 40(1), 125-129. https://doi.org/10.1016/j.clinimag.2015.07.026

Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ? / Rahbar, Habib; Parsian, Sana; Lam, Diana L.; Dontchos, Brian N.; Andeen, Nicole; Rendi, Mara H.; Lehman, Constance D.; Partridge, Savannah C.

In: Clinical Imaging, Vol. 40, No. 1, 30.06.2015, p. 125-129.

Research output: Contribution to journalArticle

Rahbar, H, Parsian, S, Lam, DL, Dontchos, BN, Andeen, N, Rendi, MH, Lehman, CD & Partridge, SC 2015, 'Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ?', Clinical Imaging, vol. 40, no. 1, pp. 125-129. https://doi.org/10.1016/j.clinimag.2015.07.026
Rahbar, Habib ; Parsian, Sana ; Lam, Diana L. ; Dontchos, Brian N. ; Andeen, Nicole ; Rendi, Mara H. ; Lehman, Constance D. ; Partridge, Savannah C. / Can MRI biomarkers at 3 T identify low-risk ductal carcinoma in situ?. In: Clinical Imaging. 2015 ; Vol. 40, No. 1. pp. 125-129.
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