Can herbs provide a new generation of drugs for treating Alzheimer's disease?

Thimmappa S. Anekonda, P (Hemachandra) Reddy

    Research output: Contribution to journalArticle

    101 Citations (Scopus)

    Abstract

    The overall aim of this review is to discuss cellular mechanisms at work in the progression of AD and current therapeutic strategies for treating AD, with a focus on the potential efficacy of herbal treatments. Recent advances in molecular, cellular, and animal model studies have revealed that formation of the 4-kDa amyloid beta peptide is a key factor in the development and progression of AD. Several cellular changes have been identified that are related to amyloid beta plaques and neurofibrillary tangles found in the autopsied brains of AD patients and in AD animal models. Several therapeutic strategies have been developed to treat AD, including anti-inflammatory, anti-oxidant, and anti-amyloid approaches. Recently, herbal treatments have been tested in animal and cellular models of AD and in clinical trials with AD subjects. In AD animal models and cell models, herbal extracts appear to have fewer adverse effects than beneficial effects on Aβ and cognitive functions. These extracts have multi-functional properties (pro-cholinergic, anti-oxidant, anti-amyloid, and anti-inflammatory), and their use in the treatment of AD patients looks promising. The chemical compositions of herbs and their potential for alleviating or reducing symptoms of AD or for affecting the disease mechanism need to be further studied.

    Original languageEnglish (US)
    Pages (from-to)361-376
    Number of pages16
    JournalBrain Research Reviews
    Volume50
    Issue number2
    DOIs
    StatePublished - Dec 15 2005

    Fingerprint

    Alzheimer Disease
    Animal Models
    Amyloid
    Oxidants
    Pharmaceutical Preparations
    Anti-Inflammatory Agents
    Neurofibrillary Tangles
    Molecular Models
    Amyloid beta-Peptides
    Amyloid Plaques
    Therapeutics
    Cognition
    Cholinergic Agents
    Clinical Trials
    Brain

    Keywords

    • Alzheimer's disease
    • Animal model
    • Bioavailability
    • Herbal drug
    • In vitro model
    • Mitochondria

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Can herbs provide a new generation of drugs for treating Alzheimer's disease? / Anekonda, Thimmappa S.; Reddy, P (Hemachandra).

    In: Brain Research Reviews, Vol. 50, No. 2, 15.12.2005, p. 361-376.

    Research output: Contribution to journalArticle

    Anekonda, Thimmappa S. ; Reddy, P (Hemachandra). / Can herbs provide a new generation of drugs for treating Alzheimer's disease?. In: Brain Research Reviews. 2005 ; Vol. 50, No. 2. pp. 361-376.
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