Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?

Michelle Meyer, Delphine C. Malherbe, Alexander Bukreyev

    Research output: Contribution to journalReview articlepeer-review

    12 Scopus citations

    Abstract

    Testing vaccine efficacy against the highly lethal Ebola virus (EBOV) in humans is almost impossible due to obvious ethical reasons and the sporadic nature of outbreaks. For such situations, the ‘animal rule’ was established, requiring the product be tested in animal models, expected to predict the response observed in humans. For vaccines, this testing aims to identify immune correlates of protection, such as antibody or cell-mediated responses. In the wake of the 2013–2016 EBOV epidemic, and despite advancement of promising candidates into clinical trials, protective correlates remain ambiguous. In the hope of identifying a reliable correlate by comparing preclinical and clinical trial data on immune responses to vaccination, we conclude that correlates are not universal for all EBOV vaccines.

    Original languageEnglish (US)
    Pages (from-to)8-16
    Number of pages9
    JournalTrends in microbiology
    Volume27
    Issue number1
    DOIs
    StatePublished - Jan 2019

    Keywords

    • Ebola
    • immune correlates
    • immunity
    • protection
    • vaccine

    ASJC Scopus subject areas

    • Microbiology
    • Microbiology (medical)
    • Infectious Diseases
    • Virology

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