cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

Mark R. Vossler, Hong Yao, Randall D. York, Ming Gui Pan, Caroline S. Rim, Philip J.S. Stork

Research output: Contribution to journalArticle

914 Scopus citations

Abstract

Cyclic adenosine monophosphate (cAMP) has tissue-specific effects on growth, differentiation, and gene expression. We show here that cAMP can activate the transcription factor Elk-1 and induce neuronal differentiation of PC12 cells via its activation of the MAP kinase cascade. These cell type- specific actions of cAMP require the expression of the serine/threonine kinase B-Raf and activation of the small G protein Rap1. Rap1, activated by mutation or by the cAMP-dependent protein kinase PKA, is a selective activator of B-Raf and an inhibitor of Raf-1. Therefore, in B-Raf-expressing cells, the activation of Rap1 provides a mechanism for tissue-specific regulation of cell growth and differentiation via MAP kinase.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalCell
Volume89
Issue number1
DOIs
StatePublished - Apr 4 1997

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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