CaM-kinases: Modulators of synaptic plasticity

Thomas R. Soderling

Research output: Contribution to journalReview articlepeer-review

199 Scopus citations

Abstract

Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses, and studies over the past two to three years have identified key functions for Ca2+/calmodulin-dependent protein kinases II and IV (CaM-KII and CaM-KIV). Sustained activation of CaM-KII localized at the postsynaptic density results in phosphorylation of numerous synaptic substrates including ion channels, other signaling molecules and scaffolding proteins, to modulate synaptic transmission within minutes. More prolonged responses may be effected through enhanced dendritic protein synthesis of CaM-KII and regulation of nuclear gene transcription by CaM-KIV.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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