Abstract
The self-association of the tranquilizer chlorpromazine hydrochloride in aqueous solution was studied. Using isothermal titration calorimetry, the critical micelle concentration and solvent-micelle interactions were evaluated as a function of temperature, ionic strength, and pH. The enthalpy of demicellization, ΔHdemic, was directly measured from the experimental enthalpy values, which showed that the spontaneous demicellization of chlorpromazine hydrochloride is a highly endothermic process under all experimental conditions studied. The thermodynamic parameters were subsequently calculated from the temperature dependent thermograms. At 25 °C, the critical micelle concentration was determined to be 3.2 mM at pH 6.5 with a ΔHdemic of 12.5 kJ/mol, a ΔGdemic of 24.3 kJ/mol, and a TΔSdemic of -10.1 kJ/mol. Our results suggest that the enthalpy-entropy compensation theory may be applied to these micelles. In addition, using differential scanning calorimetry, a broad endothermic demicellization peak was observed in postmicelle solutions during heating scans at approximately 45 °C. Cooling scans revealed a very broad peak centered around 40 °C that corresponds to the heat of micellization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6391-6395 |
| Number of pages | 5 |
| Journal | Langmuir |
| Volume | 16 |
| Issue number | 16 |
| DOIs | |
| State | Published - Aug 8 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Colloid and Surface Chemistry
- Physical and Theoretical Chemistry
Cite this
Calorimetry studies of chlorpromazine hydrochloride in solution. / Saito, Yoshihito David; Tehrani, Shandiz; Okamoto, Manko M.; Chang, Henry H.; Dea, Phoebe.
In: Langmuir, Vol. 16, No. 16, 08.08.2000, p. 6391-6395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calorimetry studies of chlorpromazine hydrochloride in solution
AU - Saito, Yoshihito David
AU - Tehrani, Shandiz
AU - Okamoto, Manko M.
AU - Chang, Henry H.
AU - Dea, Phoebe
PY - 2000/8/8
Y1 - 2000/8/8
N2 - The self-association of the tranquilizer chlorpromazine hydrochloride in aqueous solution was studied. Using isothermal titration calorimetry, the critical micelle concentration and solvent-micelle interactions were evaluated as a function of temperature, ionic strength, and pH. The enthalpy of demicellization, ΔHdemic, was directly measured from the experimental enthalpy values, which showed that the spontaneous demicellization of chlorpromazine hydrochloride is a highly endothermic process under all experimental conditions studied. The thermodynamic parameters were subsequently calculated from the temperature dependent thermograms. At 25 °C, the critical micelle concentration was determined to be 3.2 mM at pH 6.5 with a ΔHdemic of 12.5 kJ/mol, a ΔGdemic of 24.3 kJ/mol, and a TΔSdemic of -10.1 kJ/mol. Our results suggest that the enthalpy-entropy compensation theory may be applied to these micelles. In addition, using differential scanning calorimetry, a broad endothermic demicellization peak was observed in postmicelle solutions during heating scans at approximately 45 °C. Cooling scans revealed a very broad peak centered around 40 °C that corresponds to the heat of micellization.
AB - The self-association of the tranquilizer chlorpromazine hydrochloride in aqueous solution was studied. Using isothermal titration calorimetry, the critical micelle concentration and solvent-micelle interactions were evaluated as a function of temperature, ionic strength, and pH. The enthalpy of demicellization, ΔHdemic, was directly measured from the experimental enthalpy values, which showed that the spontaneous demicellization of chlorpromazine hydrochloride is a highly endothermic process under all experimental conditions studied. The thermodynamic parameters were subsequently calculated from the temperature dependent thermograms. At 25 °C, the critical micelle concentration was determined to be 3.2 mM at pH 6.5 with a ΔHdemic of 12.5 kJ/mol, a ΔGdemic of 24.3 kJ/mol, and a TΔSdemic of -10.1 kJ/mol. Our results suggest that the enthalpy-entropy compensation theory may be applied to these micelles. In addition, using differential scanning calorimetry, a broad endothermic demicellization peak was observed in postmicelle solutions during heating scans at approximately 45 °C. Cooling scans revealed a very broad peak centered around 40 °C that corresponds to the heat of micellization.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034250632&partnerID=8YFLogxK
U2 - 10.1021/la991297l
DO - 10.1021/la991297l
M3 - Article
AN - SCOPUS:0034250632
VL - 16
SP - 6391
EP - 6395
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 16
ER -