Calorimetry studies of chlorpromazine hydrochloride in solution

Yoshihito David Saito, Shandiz Tehrani, Manko M. Okamoto, Henry H. Chang, Phoebe Dea

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The self-association of the tranquilizer chlorpromazine hydrochloride in aqueous solution was studied. Using isothermal titration calorimetry, the critical micelle concentration and solvent-micelle interactions were evaluated as a function of temperature, ionic strength, and pH. The enthalpy of demicellization, ΔHdemic, was directly measured from the experimental enthalpy values, which showed that the spontaneous demicellization of chlorpromazine hydrochloride is a highly endothermic process under all experimental conditions studied. The thermodynamic parameters were subsequently calculated from the temperature dependent thermograms. At 25 °C, the critical micelle concentration was determined to be 3.2 mM at pH 6.5 with a ΔHdemic of 12.5 kJ/mol, a ΔGdemic of 24.3 kJ/mol, and a TΔSdemic of -10.1 kJ/mol. Our results suggest that the enthalpy-entropy compensation theory may be applied to these micelles. In addition, using differential scanning calorimetry, a broad endothermic demicellization peak was observed in postmicelle solutions during heating scans at approximately 45 °C. Cooling scans revealed a very broad peak centered around 40 °C that corresponds to the heat of micellization.

Original languageEnglish (US)
Pages (from-to)6391-6395
Number of pages5
JournalLangmuir
Volume16
Issue number16
DOIs
StatePublished - Aug 8 2000
Externally publishedYes

Fingerprint

chlorpromazine
Chlorpromazine
hydrochlorides
Calorimetry
Enthalpy
micelles
heat measurement
Critical micelle concentration
Micelles
enthalpy
tranquilizers
Micellization
Ionic strength
Titration
thermograms
Differential scanning calorimetry
Entropy
Association reactions
Thermodynamics
titration

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

Cite this

Saito, Y. D., Tehrani, S., Okamoto, M. M., Chang, H. H., & Dea, P. (2000). Calorimetry studies of chlorpromazine hydrochloride in solution. Langmuir, 16(16), 6391-6395. https://doi.org/10.1021/la991297l

Calorimetry studies of chlorpromazine hydrochloride in solution. / Saito, Yoshihito David; Tehrani, Shandiz; Okamoto, Manko M.; Chang, Henry H.; Dea, Phoebe.

In: Langmuir, Vol. 16, No. 16, 08.08.2000, p. 6391-6395.

Research output: Contribution to journalArticle

Saito, YD, Tehrani, S, Okamoto, MM, Chang, HH & Dea, P 2000, 'Calorimetry studies of chlorpromazine hydrochloride in solution', Langmuir, vol. 16, no. 16, pp. 6391-6395. https://doi.org/10.1021/la991297l
Saito, Yoshihito David ; Tehrani, Shandiz ; Okamoto, Manko M. ; Chang, Henry H. ; Dea, Phoebe. / Calorimetry studies of chlorpromazine hydrochloride in solution. In: Langmuir. 2000 ; Vol. 16, No. 16. pp. 6391-6395.
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