Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

Gary A. Wayman, Yong Seok Lee, Hiroshi Tokumitsu, Alcino Silva, Thomas R. Soderling

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    386 Scopus citations

    Abstract

    In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca2+/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.

    Original languageEnglish (US)
    Pages (from-to)914-931
    Number of pages18
    JournalNeuron
    Volume59
    Issue number6
    DOIs
    StatePublished - Sep 25 2008

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    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Wayman, G. A., Lee, Y. S., Tokumitsu, H., Silva, A., & Soderling, T. R. (2008). Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity. Neuron, 59(6), 914-931. https://doi.org/10.1016/j.neuron.2008.08.021