Calmodulin-Kinases

Modulators of Neuronal Development and Plasticity

Gary A. Wayman, Yong Seok Lee, Hiroshi Tokumitsu, Alcino Silva, Thomas Soderling

    Research output: Contribution to journalArticle

    374 Citations (Scopus)

    Abstract

    In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca2+/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.

    Original languageEnglish (US)
    Pages (from-to)914-931
    Number of pages18
    JournalNeuron
    Volume59
    Issue number6
    DOIs
    StatePublished - Sep 25 2008

    Fingerprint

    Calcium-Calmodulin-Dependent Protein Kinases
    Neuronal Plasticity
    Calcium-Calmodulin-Dependent Protein Kinase Type 2
    Phosphotransferases
    Protein Kinases
    Calcium-Calmodulin-Dependent Protein Kinase Kinase
    Calmodulin
    Nervous System
    Signal Transduction
    Phosphorylation
    Learning
    Calcium
    Genes
    Proteins

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Wayman, G. A., Lee, Y. S., Tokumitsu, H., Silva, A., & Soderling, T. (2008). Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity. Neuron, 59(6), 914-931. https://doi.org/10.1016/j.neuron.2008.08.021

    Calmodulin-Kinases : Modulators of Neuronal Development and Plasticity. / Wayman, Gary A.; Lee, Yong Seok; Tokumitsu, Hiroshi; Silva, Alcino; Soderling, Thomas.

    In: Neuron, Vol. 59, No. 6, 25.09.2008, p. 914-931.

    Research output: Contribution to journalArticle

    Wayman, GA, Lee, YS, Tokumitsu, H, Silva, A & Soderling, T 2008, 'Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity', Neuron, vol. 59, no. 6, pp. 914-931. https://doi.org/10.1016/j.neuron.2008.08.021
    Wayman GA, Lee YS, Tokumitsu H, Silva A, Soderling T. Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity. Neuron. 2008 Sep 25;59(6):914-931. https://doi.org/10.1016/j.neuron.2008.08.021
    Wayman, Gary A. ; Lee, Yong Seok ; Tokumitsu, Hiroshi ; Silva, Alcino ; Soderling, Thomas. / Calmodulin-Kinases : Modulators of Neuronal Development and Plasticity. In: Neuron. 2008 ; Vol. 59, No. 6. pp. 914-931.
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