Calculated cancer risks for conventional and "potentially reduced exposure product" cigarettes

James F. Pankow, Karen Watanabe-Sailor, Patricia L. Toccalino, Wentai Luo, Donald F. Austin

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Toxicant deliveries (by machine smoking) are compiled and associated cancer risks are calculated for 13 carcinogens from 26 brands of conventional cigarettes categorized as "regular" (R), "light" (Lt), or "ultralight" (ULt), and for a reference cigarette. Eight "potentially reduced exposure product" (PREP) cigarettes are also considered. Because agency-to-agency differences exist in the cancer slope factor (CSF) values adopted for some carcinogens, two CSF sets were used in the calculations: set I [U.S. Environmental Protection Agency (EPA)-accepted values plus California EPA-accepted values as needed to fill data gaps] and set II (vice versa). The potential effects of human smoking patterns on cigarette deliveries are considered. Acetaldehyde, 1,3-butadiene, and acrylonitrile are associated with the largest calculated cancer risks for all 26 brands of conventional cigarettes. The calculated risks are proportional to the smoking dose z (pack-years). Using CSF set I and z = 1 pack-year (7,300 cigarettes), the calculated brand-average incremental lifetime cancer risk ILCR1 acetaldehyde values are R, 6 × 10-5; Lt, 5 × 10-5; and ULt, 3 × 10-5 (cf. typical U.S. EPA risk benchmark of 10-6). These values are similar, especially given the tendency of smokers to "compensate" when smoking Lt and ULt cigarettes. ILCR1subΣ-lung is the brand-average per pack-year subtotal risk for the measured human lung carcinogens. Using CSF set I, the ILCR1subΣ-lung values for R, Lt, and ULt cigarettes account for ≤2% of epidemiologically observed values of the all-smoker population average per pack-year risk of lung cancer from conventional cigarettes. RPREP (%) is a science-based estimate of the possible reduction in lung cancer risk provided by a particular PREP as compared with conventional cigarettes. Using CSF set I, all RPREP values are

Original languageEnglish (US)
Pages (from-to)584-592
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number3
DOIs
StatePublished - Mar 2007

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Tobacco Products
Neoplasms
United States Environmental Protection Agency
Smoking
Carcinogens
Acetaldehyde
Lung
Lung Neoplasms
Acrylonitrile
Benchmarking

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Calculated cancer risks for conventional and "potentially reduced exposure product" cigarettes. / Pankow, James F.; Watanabe-Sailor, Karen; Toccalino, Patricia L.; Luo, Wentai; Austin, Donald F.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 3, 03.2007, p. 584-592.

Research output: Contribution to journalArticle

Pankow, James F. ; Watanabe-Sailor, Karen ; Toccalino, Patricia L. ; Luo, Wentai ; Austin, Donald F. / Calculated cancer risks for conventional and "potentially reduced exposure product" cigarettes. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 3. pp. 584-592.
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