Calcium/calmodulin-dependent protein kinase II: role in learning and memory

Thomas R. Soderling

    Research output: Contribution to journalArticlepeer-review

    75 Scopus citations


    Numerous studies over the past decade have established a role(s) for protein phosphorylation in modulation of synaptic efficiency. This article reviews this data and focuses on putative functions of Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) which is highly concentrated at these synapses which utilize glutamate as the neurotransmitter. Evidence is presented that CaM-kinase II can phosphorylate these glutamate receptor/ion channels and enhance the ion current flowing through them. This may contribute to mechanisms of synaptic plasticity that are important in cellular paradigms of learning and memory such as long-term potentiation in the hippocampus.

    Original languageEnglish (US)
    Pages (from-to)93-101
    Number of pages9
    JournalMolecular and Cellular Biochemistry
    Issue number1
    StatePublished - Nov 1 1993


    • learning and memory
    • protein phosphorylation
    • synaptic plasticity

    ASJC Scopus subject areas

    • Molecular Biology
    • Clinical Biochemistry
    • Cell Biology


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