Calcium/calmodulin-dependent protein kinase II

role in learning and memory

Thomas Soderling

    Research output: Contribution to journalArticle

    72 Citations (Scopus)

    Abstract

    Numerous studies over the past decade have established a role(s) for protein phosphorylation in modulation of synaptic efficiency. This article reviews this data and focuses on putative functions of Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) which is highly concentrated at these synapses which utilize glutamate as the neurotransmitter. Evidence is presented that CaM-kinase II can phosphorylate these glutamate receptor/ion channels and enhance the ion current flowing through them. This may contribute to mechanisms of synaptic plasticity that are important in cellular paradigms of learning and memory such as long-term potentiation in the hippocampus.

    Original languageEnglish (US)
    Pages (from-to)93-101
    Number of pages9
    JournalMolecular and Cellular Biochemistry
    Volume127-128
    Issue number1
    DOIs
    StatePublished - Nov 1993

    Fingerprint

    Calcium-Calmodulin-Dependent Protein Kinase Type 2
    Calcium-Calmodulin-Dependent Protein Kinases
    Learning
    Data storage equipment
    Phosphorylation
    Neuronal Plasticity
    Long-Term Potentiation
    Glutamate Receptors
    Ion Channels
    Synapses
    Plasticity
    Neurotransmitter Agents
    Glutamic Acid
    Hippocampus
    Modulation
    Ions
    Efficiency
    Proteins

    Keywords

    • learning and memory
    • protein phosphorylation
    • synaptic plasticity

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Clinical Biochemistry
    • Cell Biology

    Cite this

    Calcium/calmodulin-dependent protein kinase II : role in learning and memory. / Soderling, Thomas.

    In: Molecular and Cellular Biochemistry, Vol. 127-128, No. 1, 11.1993, p. 93-101.

    Research output: Contribution to journalArticle

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