Calcium/calmodulin-dependent protein kinase II.

R. J. Colbran, Thomas Soderling

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

There is a great deal known about the in vitro properties of CaM kinase II, both in terms of its substrate specificity and its regulation by calmodulin and autophosphorylation. Much of this characterization is based on experiments performed with the rat brain isozyme of CaM kinase II, although in the aspects examined to date isozymes of the kinase from other tissues appear to behave in a broadly similar manner in vitro. However, relatively little is known about the functions of the kinase in vivo. The proteins phosphorylated by the kinase (with the probable exception of synapsin I and tyrosine hydroxylase) and the role of kinase autophosphorylation in vivo remain largely unknown. Investigation of the physiological role of the kinase in brain and other tissues will be a particularly exciting area for future work. The current knowledge of the in vitro properties and the availability of cDNA clones will hopefully expedite this research.

Original languageEnglish (US)
Pages (from-to)181-221
Number of pages41
JournalCurrent topics in cellular regulation
Volume31
StatePublished - 1990
Externally publishedYes

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Phosphotransferases
Isoenzymes
Synapsins
Brain
Tyrosine 3-Monooxygenase
Calmodulin
Substrate Specificity
Protein Kinases
Complementary DNA
Clone Cells
Research
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Colbran, R. J., & Soderling, T. (1990). Calcium/calmodulin-dependent protein kinase II. Current topics in cellular regulation, 31, 181-221.

Calcium/calmodulin-dependent protein kinase II. / Colbran, R. J.; Soderling, Thomas.

In: Current topics in cellular regulation, Vol. 31, 1990, p. 181-221.

Research output: Contribution to journalArticle

Colbran, RJ & Soderling, T 1990, 'Calcium/calmodulin-dependent protein kinase II.', Current topics in cellular regulation, vol. 31, pp. 181-221.
Colbran, R. J. ; Soderling, Thomas. / Calcium/calmodulin-dependent protein kinase II. In: Current topics in cellular regulation. 1990 ; Vol. 31. pp. 181-221.
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